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Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are
TLDR
There is strong evidence that adenosine mediates the antiinflammatory effects of MTX in this model of RA, and the findings suggest that abstinence from caffeine, a ubiquitous food additive and medication, may enhance the therapeutic effects ofMTX in RA. Expand
Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis
TLDR
It is demonstrated that hepatic adenosine A2A receptors play an active role in the pathogenesis of hepatic fibrosis, and a novel therapeutic target is suggested in the treatment and prevention of Hepatic cirrhosis. Expand
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.
TLDR
Findings confirm that adenosine, acting at A(2A) and A(3) receptors, is a potent regulator of inflammation. Expand
The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.
TLDR
It is concluded that the distinct adenosine system of newborns polarizes TLR-mediated cytokine production during the perinatal period and may thereby modulate their innate and adaptive immune responses. Expand
Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.
TLDR
It is found that the transcription factor SOX9 is necessary for MEC plasticity in airway regeneration and SMG-derived cells display multipotency and contribute to basal and luminal cell types of the SMGs and SE. Expand
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.
TLDR
It is demonstrated that adenosine A2A receptors play an active role in the pathogenesis of dermal fibrosis and suggest a novel therapeutic target in the treatment and prevention of der mal fibrosis in diseases such as scleroderma. Expand
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.
TLDR
Targeting the adenosine A(2A) receptor is a novel approach to promoting wound healing and angiogenesis in normal individuals and those suffering from chronic wounds. Expand
Adenosine A2A Receptor Stimulation Increases Angiogenesis by Down-Regulating Production of the Antiangiogenic Matrix Protein Thrombospondin 1
TLDR
The results indicate that the angiogenic effects of adenosine A2A receptor activation are, at least in part, caused by the suppression of TSP1 secretion. Expand
Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis
TLDR
Low-dose, weekly methotrexate treatment increased the adenosine concentration in the peritoneal exudates of all mice studied, and reduced the leukocyte accumulation in the wild-type mice and A3 receptors knockout mice but not in the A2A receptor knockout mice, providing strong evidence that the anti-inflammatory effects of methotreysine are mediated by different receptors in different inflammatory loci. Expand
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia.
TLDR
The results suggest that improvement in oral exposure could improve the in vivo efficacy of this series, and the best compound showed good in vivo activity when administered intraperitoneally but was not active by oral route. Expand
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