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Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.
- G. Garcea, D. Berry, +6 authors A. Gescher
- Cancer epidemiology, biomarkers & prevention : a…
The results suggest that a daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution ofCurcumin outside the gut. Expand
Liver Resection Versus Transplantation for Hepatocellular Carcinoma in Cirrhotic Patients
- H. Bismuth, L. Chiche, R. Adam, D. Castaing, T. Diamond, A. Dennison
- Annals of surgery
- 1 August 1993
The best indication for transplantation seems to be patients with small and uninodular or binodular tumors; until now, these patients were considered to be the best candidates for resection. Expand
Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences
The high silibinin levels achieved in the human colorectal mucosa after consumption of safe silib inin doses support its further exploration as a potential human coloresctal cancer chemopreventive agent. Expand
Prognostic molecular markers in hepatocellular carcinoma: a systematic review.
- C. Mann, C. P. Neal, G. Garcea, M. Manson, A. Dennison, D. Berry
- European journal of cancer
- 1 April 2007
A number of molecular biomarkers with prognostic significance have been identified in hepatocellular carcinoma and not only might these molecules allow more accurate prediction of prognosis for patients with HCC, but they may also provide targets for potential therapeutic agents. Expand
Subtotal hepatectomy: a porcine model for the study of liver regeneration.
The hypothesis that 90% partial hepatectomy represents a model of critical residual liver parenchyma is supported and the techniques have been shown to be easily reproducible and well tolerated by the animals and allow easy assessment of liver function and regeneration in the postoperative period. Expand
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
The results suggest that doses of curcumin required to furnish hepatic levels sufficient to exert pharmacological activity are probably not feasible in humans. Expand
Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) is Associated with Reduced Disease-free Survival Following Curative Resection of Pancreatic Adenocarcinoma
- G. Garcea, N. Ladwa, C. P. Neal, M. Metcalfe, A. Dennison, D. Berry
- World Journal of Surgery
- 11 February 2011
Preoperative NLR offers important prognostic information regarding disease-free survival following curative resection of pancreatic ductal adenocarcinoma and Kaplan-Meier survival analysis of patients with NLR > 5 demonstrated a disease- free survival of 12 months compared with 52 months for those patients withNLR < 5 (p < 0.001). Expand
Prediction of Mortality in Acute Pancreatitis: A Systematic Review of the Published Evidence
Despite the proliferation of scoring systems for grading AP, none are ideal for the prediction of mortality, and with the exception of the APACHE II, the other scores and indexes do not have a high degree of sensitivity, specificity and predictive values. Expand
Tissue collection, transport and isolation procedures required to optimize human hepatocyte isolation from waste liver surgical resections. A multilaboratory study
- L. Richert, E. Alexandre, +9 authors D. Jaeck
- Liver international : official journal of the…
- 1 August 2004
The European Center for Validation of Alternative Methods has funded a prevalidation study in three laboratories on the use of human hepatocyte cultures to predict cytochrome P‐450 induction. Expand
Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases.
The presence of a pre-operative systemic inflammatory response, but not socioeconomic deprivation, independently predicts shortened survival following resection ofclinopathological data for 174 patients who underwent hepatectomy for CLM. Expand