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l-Acetylcarnitine in dysthymic disorder in elderly patients: A double-blind, multicenter, controlled randomized study vs. fluoxetine
Headache and noradrenergic involvement: the effects of alpha 2-stimulants and alpha 2-antagonists.
- A. Denaro, N. Martucci, S. Ruggieri, V. Manna, A. Agnoli
- Medicine, PsychologyActa psychiatrica Scandinavica. Supplementum
Clonidine significantly decreased headache intensity at 90 days in the common migraine group and mianserin had significantly reduced the Hamilton Depression Rating Scale (HDRS) mean total score, (in the tension headache group),HDRS mean anxiety cluster scores (in both groups), and the HDRS mean depression cluster score ( in the tension headaches group).
THIP treatment of Huntington's disease
CSF content of homovanillic acid, a major metabolite of dopamine, increased during high-dose THIP therapy, suggesting that augmentation of dopamine function may have contributed to the drug's lack of efficacy.
Plasma growth hormone and prolactin response to dopaminergic GABAmimetic and cholinergic stimulation in Huntington's disease
Loss of somatostatin activity in the hypothalamic-pituitary axis in Huntington's disease could account for these endocrinologic changes.
The role of MAO-b inhibitors in the treatment of Parkinson's disease.
- S. Ruggieri, F. Stocchi, A. Denaro, F. Baronti, A. Agnoli
- Biology, MedicineJournal of neural transmission. Supplementum
Deprenyl is a selective MAO-B inhibitor thought to be able to slow down the catabolism of dopamine and therefore to allow a decrease of the therapeutic regimen of L-dopa while in the meantime to obtain a more stable plasma and tissue levels and a constant therapeutic response.
Wearing-off detection in clinical practice: the wearing off real practice key (WORK-PD) study in Parkinson's disease.
New strategies in the management of Parkinson's disease: a biological approach using a phospholipid precursor (CDP-choline).
The positive effect of CDP-choline on parkinsonian patients already treated with L-dopa + dopa decarboxylase inhibitor stands for a possible action on the DA receptor through an activation of the phospholipid metabolism.
Efficacy of Cytidine Diphosphate Choline in Patients Affected by Chronic Cerebrovascular Disease
Patients treated with CDP-choline demonstrated a significant improvement in cognitive functions, while the placebo-treated patients did not show any significant trend.
Headache and noradrenergic involvement: the effects of α2‐stimulants and α2‐antagonists
Clonidine significantly decreased headache intensity at 90 days in the common migraine group and mianserin had significantly reduced the Hamilton Depression Rating Scale (HDRS) mean total score, (in the tension headache group), and HDRS mean anxiety cluster scores (in both groups).
Ability of a Set of Trunk Inertial Indexes of Gait to Identify Gait Instability and Recurrent Fallers in Parkinson’s Disease
HR and RQAdet in the antero-posterior direction can both be used as age- and-speed-independent markers of gait instability, and was correlated with stride duration and cadence.