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Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells.
TLDR
In bone marrow from rat and human, beta(2)m(-)/Thy-1(+) cells consistently express liver-specific genes and functions, and this differentiation was dependent on a yet nondescript humoral signal existing in the cholestatic serum.
Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells
TLDR
Results of this study indicate that BMSCs could facilitate proliferation and differentiation of primary rat hepatocytes and their progenitors (SH) in vitro.
Bioartificial liver support.
TLDR
The authors review the history of extracorporeal liver support for acute liver failure and discuss their experience with a hollow fiber bioartificial liver support system utilizing porcine hepatocytes in the treatment of patients with acute Liver failure.
Fulminant hepatic failure in rats: Survival and effect on blood chemistry and liver regeneration
TLDR
A novel model of FHF in rats is developed that has a number of physiological and biochemical features seen clinically in FHF, including severely impaired ability of the residual liver tissue to regenerate, and changes in blood chemistry reflected rapid development of liver failure.
Review: Artificial liver support systems
TLDR
In a preliminary clinical study, a porcine hepatocyte‐based liver support system is used to treat patients with acute liver failure as well as Patients with acute exacerbation of chronic liver disease, successfully bridged to a transplant with excellent survival.
Isolated hepatocytes in a bioartificial liver: A single group view and experience
TLDR
The authors conclude that BAL treatment with porcine hepatocytes appears to be safe and can help maintain patients alive and neurologically intact until a liver becomes available for transplantation.
Liver Assist Systems: State of the Art
TLDR
The authors review the current status of liver assist systems and summarize their clinical experience with a xenogeneic cell based-bioartificial liver.
Loss and recovery of liver regeneration in rats with fulminant hepatic failure.
TLDR
Whether syngeneic isolated hepatocytes transplanted in the spleen will prolong survival and facilitate liver regeneration in FHF rats is investigated and Hepatocyte transplantation prolonged survival and facilitated liver regeneration.
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