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NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test
A role for NMDAR signalling in the antidepressant-like effects of lithium, providing a new approach for treatment of depression, is suggested for the first time. Expand
Endogenous cannabinoids contribute to remote ischemic preconditioning via cannabinoid CB2 receptors in the rat heart.
The results of this study suggest that endogenous cannabinoids, through acting on cannabinoid CB(2) receptors, are involved in the cardioprotective phenomenon of remote ischemic preconditioning, induced by mesenteric artery occlusion and reperfusion. Expand
The proconvulsant effect of sildenafil in mice: role of nitric oxide–cGMP pathway
Sildenafil induces a proconvulsant effect on clonic seizure threshold that interacts with both exogenously and endogenously released NO and may be linked to activation of NO–cGMP pathway. Expand
Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies.
Ex vivo investigations revealed better insulin transport across the colon membrane of rats for nanoparticles made with quaternized derivatives than those made of chitosan, and enhanced colon absorption of insulin by using these nanoparticles compared to free insulin in diabetic rats. Expand
Neurobiology and consequences of social isolation stress in animal model-A comprehensive review.
In several regions of the central nervous system (CNS), SIS alters the level of neurotransmitter such as dopamine, serotonin, gamma aminobutyric acid, glutamate, nitrergic system and adrenaline as well as leads to alteration in receptor sensitivity of N-methyl-D-aspartate (NMDA) and opioid system. Expand
Morphine is protective against doxorubicin-induced cardiotoxicity in rat.
Since morphine had very good protective effects against a high dose of DOX given as a multiple, low, unitary dose regimen, not only on the heart but on the whole rat as well, it could be recommended for further investigation in this potentially new indication for clinical application. Expand
Agmatine exerts anticonvulsant effect in mice: modulation by α2-adrenoceptors and nitric oxide
Abstract The effect of agmatine, an endogenous polyamine metabolite, on seizure susceptibility was investigated in mice. Acute intraperitoneal administration of agmatine (5, 10, 20, 40 mg/kg) had aExpand
Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system
Comparisons between socially and isolated conditioned (SC and IC) animals showed that SIS induces behaviors relevant to depression and anxiety in IC mice and in addition, nitrergic system is involved in mediating the negative outcomes of SIS, and confirmed that Sis is an appropriate animal model to investigate the potential mechanisms in depression-anxiety co-occurrence. Expand
Protective effects of sildenafil administration on testicular torsion/detorsion damage in rats
The results of biochemical studies suggest that, reduction of oxidative stress by sildenafil may have a major role in its cytoprotective effects and reduce ischemia/reperfusion cellular damage. Expand
The role of nitric oxide in orthodontic tooth movement in rats.
A role for NO in the bone remodeling cycle is suggested by researchers investigating the role of NO in orthodontic tooth movement by establishing a rat model and finding that the number of osteoclasts in the L-arg group was significantly lower as compared to the control group. Expand