• Publications
  • Influence
Therapeutic Effects of Cystamine in a Murine Model of Huntington's Disease
TLDR
Treatment in R6/2 transgenic HD mice, using the transglutaminase inhibitor cystamine, significantly extended survival, improved body weight and motor performance, and delayed the neuropathological sequela. Expand
Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile
TLDR
It is found that N-acetylaspartate, glutamate and glutathione were decreased by 17%, 22% and 36%, respectively, in the cerebral cortex of APP transgenic mice at 19 months of age when Abeta deposits are widespread, and Taurine was increased 21% compared to wild-type. Expand
Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine
TLDR
The present results indicate that a knock-out of GSHPx may be adequately compensated under nonstressed conditions, but that after administration of mitochondrial toxins GSHpx plays an important role in detoxifying increases in oxygen radicals. Expand
Application of MRS to mouse models of neurodegenerative illness
TLDR
The argument is made that use of MRS, combined with correlative histology and other MRI techniques, will enable objective markers with which potential therapies can be followed in a quantitative fashion. Expand
Therapeutic Effects of Coenzyme Q10 and Remacemide in Transgenic Mouse Models of Huntington's Disease
TLDR
It was found that oral administration of either coenzyme Q10 or remacemide significantly extended survival and delayed the development of motor deficits, weight loss, cerebral atrophy, and neuronal intranuclear inclusions in the R6/2 transgenic mouse model of HD. Expand
Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease
TLDR
Nuclear magnetic resonance spectroscopy showed that creatine supplementation significantly increased brain creatine concentrations and delayed decreases in N-acetylaspartate concentrations, supporting a role of metabolic dysfunction in a transgenic mouse model of HD and suggesting a novel therapeutic strategy to slow the pathological process. Expand
Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice
TLDR
It is reported that creatine administration started after onset of clinical symptoms significantly extends survival in the R6/2 transgenic mouse model of HD, suggesting that creatine therapy initiated after diagnosis may provide significant clinical benefits to HD patients. Expand
Moderate exercise delays the motor performance decline in a transgenic model of ALS
TLDR
The beneficial effects of moderate exercise on the preservation of motor performance that correlates with higher motor neuron density in the ventral horn of the lumbar spinal cord in G93A mice are shown. Expand
Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice
TLDR
Prophylactic treatment of young 3xTg-AD mice with ibuprofen reduces intraneuronal oligomeric Abeta, reduces cognitive deficits, and prevents hyperphosphorylated tau immunoreactivity, which provides further support for intranesuronal Abeta as a cause of cognitive impairment. Expand
The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS
TLDR
Novel evidence is provided for Klotho as a key player in myelin biology, which may be a useful therapeutic target in efforts to protect brain myelin against age-dependent changes and promote repair in multiple sclerosis. Expand
...
1
2
3
4
5
...