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Fungal endophytes: unique plant inhabitants with great promises
The chemical potential of endophytic fungi for drug discovery will be discussed with focus on the detection of pharmaceutically valuable plant constituents as products of fungal biosynthesis. Expand
Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products
This overview will highlight the chemical potential of endophytic fungi with focus on the detection of pharmaceutically valuable plant constituents, e.g. paclitaxel, camptothecin and podophyllotoxin, as products of fungal biosynthesis, and new bioactive metabolites reported in recent years from fungal endophytes of terrestrial and mangrove plants. Expand
Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products
This protocol gives a detailed description of methods useful for the isolation and cultivation of fungi associated with various marine organisms for the extraction, characterization and structure elucidation of biologically active secondary metabolites produced by these marine-derived endophytic fungi. Expand
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.
- W. Wätjen, A. Debbab, +9 authors P. Proksch
- Biology, Medicine
- Molecular nutrition & food research
- 1 April 2009
Enniatins A1 and B1 and, to a lesser extent, enniatin B may possess anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Expand
Bioactive Compounds from Marine Bacteria and Fungi
This review covers new biologically active natural products published recently and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action. Expand
Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
The endophytic fungus Stemphylium globuliferum was isolated from stem tissues of the Moroccan medicinal plant Mentha pulegium, and extracts of the fungus exhibited considerable cytotoxicity when tested in vitro against L5178Y cells. Expand
Fifty years of drug discovery from fungi
Given that estimations of fungal biodiversity exceed by far the number of already identified species, chances to find hitherto unidentified fungal species and novel bioactive fungal products are still high, further compounds with medicinal or agricultural potential from less investigated fungal taxa can be expected in the years to come. Expand
Endophytes and associated marine derived fungi—ecological and chemical perspectives
New insights into fungal-host interaction, chemical communication, and chemo-ecological roles of fungal metabolites, as well as new strategies for bioprospecting are presented. Expand
Bioactive secondary metabolites from endophytes and associated marine derived fungi
This review covers the literature published in 2010 and highlights new bioactive metabolites and known compounds for which hitherto novel biological activities have been reported. Expand
Fungal endophytes - secret producers of bioactive plant metabolites.
The uniqueness of endophytic fungi as alternative sources of pharmaceutically valuable compounds originally isolated from higher plants, e.g. paclitaxel, camptothecin and podophyllotoxin are highlighted. Expand