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MicroRNAs as a selective channel of communication between competing RNAs: a steady-state theory.
It has recently been suggested that the competition for a finite pool of microRNAs (miRNA) gives rise to effective interactions among their common targets (competing endogenous RNAs or ceRNAs) thatExpand
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RNA-based regulation: dynamics and response to perturbations of competing RNAs.
The observation that, through a titration mechanism, microRNAs (miRNAs) can act as mediators of effective interactions among their common targets (competing endogenous RNAs or ceRNAs) has broughtExpand
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ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins
Gene expression is a noisy process and several mechanisms, both transcriptional and post-transcriptional, can stabilize protein levels in cells. Much work has focused on the role of miRNAs, showingExpand
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Kinetic Modelling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs.
Non-coding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated,Expand
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Translating ceRNA Susceptibilities into Correlation Functions.
Competition to bind microRNAs induces an effective positive cross talk between their targets, which are therefore known as "competing endogenous RNAs" (ceRNAs). Although such an effect is known toExpand
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Identifying essential genes in Escherichia coli from a metabolic optimization principle
Understanding the organization of reaction fluxes in cellular metabolism from the stoichiometry and the topology of the underlying biochemical network is a central issue in systems biology. In thisExpand
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Noise processing by microRNA-mediated circuits: The Incoherent Feed-Forward Loop, revisited
The intrinsic stochasticity of gene expression is usually mitigated in higher eukaryotes by post-transcriptional regulation channels that stabilise the output layer, most notably protein levels. TheExpand
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The Mosaic Mitral Valve Bioprosthesis: A Long-Term Clinical and Hemodynamic Follow-Up.
We reviewed the cases of 100 patients (mean age, 73 ± 10 yr; 64 men) who had mitral valve replacement with a Medtronic Mosaic porcine bioprosthesis from 1995 through 2011. The mean New York HeartExpand
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Incidence of Aortitis in Surgical Specimens of the Ascending Aorta Clinical Implications at Follow-Up.
The objectives of this study are to evaluate the incidence of aortitis on a surgical population, establish any relationship with systemic diseases, verify early and late surgical results and provideExpand
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Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence ofExpand
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