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14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma. Intergroupe Francophone du
Clonal plasma cells in monoclonal gammopathy of undetermined significance (MGUS) have been shown to bear copy number chromosome changes. To extend our knowledge of MGUS to structural chromosomalExpand
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Amplification of the 11q23 region in acute myeloid leukemia
Cytogenetic abnormalities involving the 11q23 region are found in both acute lymphoblastic leukemia (ALL) and myeloid leukemia (AML). Molecular consequences of 11q23 translocations are the formationExpand
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High incidence of cryptic translocations involving the Ig heavy chain gene in multiple myeloma, as shown by fluorescence in situ hybridization
Cytogenetic studies have shown rearrangements of the Ig heavy chain (IGH) gene at 14q32 in 10–60% of patients with multiple myeloma (MM) or primary plasma cell leukemia (PCL). Analysis of MM patientsExpand
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P53 deletion is not a frequent event in multiple myeloma
Recently a high incidence of interstitial deletion of the P53 locus has been reported in multiple myeloma (MM) patients. Considering the importance of such an event, we analysed 79 patients withExpand
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Detection of t(11;14) using interphase molecular cytogenetics in mantle cell lymphoma and atypical chronic lymphocytic leukemia
The chromosomal translocation t(11;14)(q13;q32) fuses the IGH and CCND1 genes and leads to cyclin D1 overexpression. This genetic abnormality is the hallmark of mantle cell lymphoma (MCL), but isExpand
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Fluorescence in situ hybridization on peripheral-blood specimens is a reliable method to evaluate cytogenetic response in chronic myeloid leukemia.
PURPOSE To evaluate the usefulness of fluorescence in situ hybridization (FISH) on peripheral-blood specimens to evaluate the cytogenetic response to treatment in patients with chronic myeloidExpand
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Dépendance tabagique et traitement par les systèmes thérapeutiques transdermiques nicotiniques
Le tabagisme determine une double dependance, psychologique et physiologique. Parmi les nombreuses substances isolees de la fumee du tabac, la nicotine est l'element responsable de la dependanceExpand