• Publications
  • Influence
Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia
BACKGROUND: Over the past decade, the safety of anesthetic agents in children has been questioned after the discovery that immature animals exposed to anesthesia display apoptotic neurodegenerationExpand
Postoperative Mortality in Children After 101,885 Anesthetics at a Tertiary Pediatric Hospital
BACKGROUND: Mortality is a basic measure for quality and safety in anesthesia. There are few anesthesia-related mortality data available for pediatric practice. Our objective for this study was toExpand
Ethics and medical research in children
The ethics of clinical research is based on several well‐known guidelines and documents. The guidelines vary between countries, but the principles of respect for persons, beneficence, and justice areExpand
Effective postoperative pain management in children after ambulatory surgery, with a focus on tonsillectomy: barriers and possible solutions
Pain following ambulatory surgery is often poorly managed at home. Certain procedures, such as tonsillectomy, cause high levels of pain for at least 1 week postoperatively. This impacts significantlyExpand
A cohort study of the incidence and risk factors for negative behavior changes in children after general anesthesia
Background:  Hospitalization and anesthesia can have a substantial psychological impact on children, which may be manifested by negative behavioral change. The primary aims of this study were toExpand
Risk factors for anxiety at induction of anesthesia in children: a prospective cohort study
Background : In children anxiety at induction of anesthesia is a common and important aspect of the psychological impact of anesthesia and surgery. Previous studies examining risk factors forExpand
Performance of entropy and Bispectral Index as measures of anaesthesia effect in children of different ages.
BACKGROUND Entropy and Bispectral Index (BIS) have been promoted as EEG-based anaesthesia depth monitors. The EEG changes with brain maturation, but there are limited published data describing theExpand
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS)
__Background__ In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohortExpand
Anesthesia and neurotoxicity to the developing brain: the clinical relevance
Laboratory work has confirmed that general anesthetics cause increased neuronal apoptosis and changes to the morphology of dendritic spines in the developing brains of animals. It is an effect seenExpand
Awareness During Anesthesia in Children: A Prospective Cohort Study
During routine adult anesthesia, the risk of awareness is 0.1%–0.2%. No recent studies have reported the incidence in children. Altered pharmacology and differing anesthesia techniques suggest thatExpand