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Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol
The combined examination of the 21 protocols in the same dataset suggests possible strategies towards developing a harmonized subfield segmentation protocol and facilitates comparison between published studies. Expand
Striatal Iron Content Predicts Its Shrinkage and Changes in Verbal Working Memory after Two Years in Healthy Adults
The accumulation of non-heme iron in the brain has been proposed as a harbinger of neural and cognitive decline in aging and neurodegenerative disease, but support for this proposal has been drawnExpand
Age differences in hippocampal subfield volumes from childhood to late adulthood
The associations between age and volumes of CA3‐DG and the entorhinal cortex were negative in mid‐childhood and attenuated in later adulthood, and the different magnitudes and patterns of age differences in subfield volumes may reflect dynamic microstructural factors and have implications for cognitive functions across the lifespan. Expand
Age-related differences in iron content of subcortical nuclei observed in vivo: A meta-analysis
A meta-analysis of 20 in vivo magnetic resonance imaging studies that estimated iron content in the caudate nucleus, globus pallidus, putamen, red nucleus, and substantia nigra supports a robust association between advanced age and high ironcontent in the substantia Nigra and striatum. Expand
The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory.
It is concluded that the association between age-related declines in memory and reduced hippocampal volume may reflect the impact of oxidative stress related to increase in free iron concentration. Expand
Volume of the hippocampal subfields in healthy adults: differential associations with age and a pro-inflammatory genetic variant
The results support the notion that volumes of age-sensitive brain regions may be affected by pro-inflammatory factors that may be targeted by therapeutic interventions. Expand
Hippocampal CA3-dentate gyrus volume uniquely linked to improvement in associative memory from childhood to adulthood
Typical development of associative memory was largely explained by age‐related differences in CA3‐dentate gyrus, and non‐linear age differences were identified in CA1‐2 and hippocampal body volumes. Expand
Changes in Search Path Complexity and Length During Learning of a Virtual Water Maze: Age Differences and Differential Associations with Hippocampal Subfield Volumes.
Subiculum and CA1-2 volumes were associated with speed of acquisition, but not magnitude of gains in virtual maze navigation, and age differences in regional volumes collectively accounted for 23% of the age-related variance in navigation learning. Expand
Optimization and validation of automated hippocampal subfield segmentation across the lifespan
With described customization steps implemented by experts trained in MRI neuroanatomy, ASHS shows excellent concurrent validity, and can become a promising method for studying age‐related changes in HC subfield volumes. Expand
Appraising the Role of Iron in Brain Aging and Cognition: Promises and Limitations of MRI Methods
The potential advantages and promises of MRI-based assessment of brain iron, summarizes recent findings and highlights the limitations of the current methodology are described. Expand