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Theme and variations: evolutionary diversification of the HET-s functional amyloid motif
In mammals and fungi, Nod-like receptors (NLR) activate downstream cell death execution proteins by a prion-like mechanism. In Podospora anserina, the NWD2 NLR activates the HET-S Helo-domainExpand
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Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis
Significance Programmed cell death plays a central role in host defense in plants, animals, and fungi, but the extent to which cell death modalities are evolutionarily related and mechanisticallyExpand
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Genomic Clustering and Homology between HET-S and the NWD2 STAND Protein in Various Fungal Genomes
Background Prions are infectious proteins propagating as self-perpetuating amyloid polymers. The [Het-s] prion of Podospora anserina is involved in a cell death process associated with non-selfExpand
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Regulated Forms of Cell Death in Fungi
Cell death occurs in all domains of life. While some cells die in an uncontrolled way due to exposure to external cues, other cells die in a regulated manner as part of a genetically encodedExpand
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Contribution of Specific Residues of the β-Solenoid Fold to HET-s Prion Function, Amyloid Structure and Stability
The [Het-s] prion of the fungus Podospora anserina represents a good model system for studying the structure-function relationship in amyloid proteins because a high resolution solid-state NMRExpand
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Molecular Mechanisms Regulating Cell Fusion and Heterokaryon Formation in Filamentous Fungi.
For the majority of fungal species, the somatic body of an individual is a network of interconnected cells sharing a common cytoplasm and organelles. This syncytial organization contributes to anExpand
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Signal Transduction by a Fungal NOD-Like Receptor Based on Propagation of a Prion Amyloid Fold
In the fungus Podospora anserina, the [Het-s] prion induces programmed cell death by activating the HET-S pore-forming protein. The HET-s β-solenoid prion fold serves as a template for converting theExpand
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Diversity and Variability of NOD-Like Receptors in Fungi
Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular receptors that control innate immunity and other biotic interactions in animals and plants. NLRs have beenExpand
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The [Het-s] Prion, an Amyloid Fold as a Cell Death Activation Trigger
Prions are self-propagating amyloids. Amyloids are proteinpolymers with a cross-b structure, in which short b-strands fromthe monomers stack one on top of each other to make up a fibrillarpolymerExpand
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Identification of NLR-associated amyloid signaling motifs in filamentous bacteria
NLRs (Nod-like receptors) are intracellular receptors regulating immunity, symbiosis, non-self recognition and programmed cell death in animals, plants and fungi. Several fungal NLRs employ amyloidExpand
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