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Ion channels in sperm physiology.
Fertilization is a matter of life or death. In animals of sexual reproduction, the appropriate communication between mature and competent male and female gametes determines the generation of a newExpand
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Ion transport in sperm signaling.
Ion channels and transporters, key elements in sperm-egg signaling and environmental sensing, are essential for fertilization. External cues and components from the outer envelopes of the eggExpand
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The SLO3 sperm‐specific potassium channel plays a vital role in male fertility
Here we show a unique example of male infertility conferred by a gene knockout of the sperm‐specific, pH‐dependent SLO3 potassium channel. In striking contrast to wild‐type sperm which undergoExpand
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Calcium channels in the development, maturation, and function of spermatozoa.
A proper dialogue between spermatozoa and the egg is essential for conception of a new individual in sexually reproducing animals. Ca(2+) is crucial in orchestrating this unique event leading to aExpand
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Involvement of a Na+/HCO 3 − Cotransporter in Mouse Sperm Capacitation*
Mammalian sperm are incapable of fertilizing eggs immediately after ejaculation; they acquire fertilization capacity after residing in the female tract for a finite period of time. The physiologicalExpand
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Ion channels, phosphorylation and mammalian sperm capacitation.
Sexually reproducing animals require an orchestrated communication between spermatozoa and the egg to generate a new individual. Capacitation, a maturational complex phenomenon that occurs in theExpand
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Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm
Intracellular Ca2+ has an important regulatory role in the control of sperm motility, capacitation, and the acrosome reaction (AR). However, little is known about the molecular identity of theExpand
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Sperm channel diversity and functional multiplicity.
Ion channels are extraordinarily efficient machines that move ions in diversely controlled manners, allowing cells to rapidly exchange information with the outside world and with other cells.Expand
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Tuning sperm chemotaxis by calcium burst timing.
Marine invertebrate oocytes establish chemoattractant gradients that guide spermatozoa towards their source. In sea urchin spermatozoa, this relocation requires coordinated motility changes initiatedExpand
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Inwardly rectifying K(+) channels in spermatogenic cells: functional expression and implication in sperm capacitation.
To fertilize, mammalian sperm must complete a maturational process called capacitation. It is thought that the membrane potential of sperm hyperpolarizes during capacitation, possibly due to theExpand
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