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Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach
This review describes specific strategies for targeting to the central nervous system (CNS). Systemically administered drugs can reach the brain by crossing one of two physiological barriersExpand
Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy?
The present commentary surveys the methods for obtaining the thermodynamic parameters of the drug-receptor binding equilibrium, DeltaG degrees, DeltaH degrees, DeltaS degrees, and DeltaC degrees (p)Expand
Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate.
We have previously demonstrated that dopamine conjugation to glucose allows it to induce therapeutic effects against Parkinson's disease after intravenous administration. In this paper we demonstrateExpand
Brain uptake of an anti-ischemic agent by nasal administration of microparticles.
N(6)-cyclopentyladenosine (CPA) has neuronal anti-ischemic properties, but it is not absorbed into the brain from the bloodstream, where it shows poor stability and induces side effects.Expand
Adenylyl cyclases as innovative therapeutic goals.
Pharmacological modulation of intracellular cyclic AMP (cAMP) signalling could provide new therapeutic and experimental tools. Although drugs interfering with this pathway have traditionally targetedExpand
Brain targeting of resveratrol by nasal administration of chitosan‐coated lipid microparticles
Graphical abstract Figure. No caption available. &NA; Lipid microparticles (LMs) uncoated or coated with chitosan and containing the neuroprotective polyphenol resveratrol were developed for itsExpand
Soil management effects on nutritional status and grapevine performance
Dans un vignoble de Chardonnay greffe sur 3309 C on a applique diffeentes techniques d'entretien du sol, qui on a etudie pendant les cinq annees suivantes l'implantation. L'enherbement, par rapportExpand
Studies on human neutrophil biological functions by means of formyl-peptide receptor agonists and antagonists.
Phagocytes are activated by several extracellular signals, including formyl-peptides derived from bacterial proteins or disrupted cells. The most intensely studied member of the formylpeptide familyExpand
Binding thermodynamics of 5-HT1A receptor ligands.
The thermodynamic parameters delta G degree, delta H degree and delta S degree of the binding equilibrium of 15 ligands (eight agonists and seven antagonists) to the 5-HT1A receptor subtype have beenExpand
Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SVneo: effect of steroids, flavonoids and NSAIDs.
Vitamin C plays an important role in embryogenesis and fetal growth as well as in the progression of pregnancy and delivery. Therefore, it is important to understand the mechanism that mediates itsExpand