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Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach
- B. Pavan, A. Dalpiaz, Nunzia Ciliberti, C. Biondi, S. Manfredini, S. Vertuani
- 1 May 2008
This review describes specific strategies for targeting to the central nervous system (CNS) using several specific transporters identified in boundary tissues between blood and CNS compartments to explore prodrug approaches with improved brain delivery.
Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate.
Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy?
Brain uptake of an anti-ischemic agent by nasal administration of microparticles.
Ex vivo studies on sheep nasal mucosa and in vitro mucoadhesion studies indicated that CPA-loaded chitosan microparticles had higher mucocoadhesive properties compared to mannitol particles, which can open new perspectives for the employment of CPA against brain damages following stroke.
Adenylyl cyclases as innovative therapeutic goals.
Soil management effects on nutritional status and grapevine performance
Dans un vignoble de Chardonnay greffe sur 3309 C on a applique diffeentes techniques d'entretien du sol, qui on a etudie pendant les cinq annees suivantes l'implantation. L'enherbement, par rapport…
Studies on human neutrophil biological functions by means of formyl-peptide receptor agonists and antagonists.
- A. Dalpiaz, S. Spisani, C. Biondi, E. Fabbri, M. Nalli, M. E. Ferretti
- Biology, ChemistryCurrent drug targets. Immune, endocrine and…
- 28 February 2003
The aim of this review is to summarise the current understanding of the series of events that begins at the level of formylpeptide-receptor interaction and is responsible for the activation of transduction pathways, which finally determine neutrophil response.
Binding thermodynamics of 5-HT1A receptor ligands.
Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SVneo: effect of steroids, flavonoids and NSAIDs.
- C. Biondi, B. Pavan, A. Dalpiaz, S. Medici, L. Lunghi, F. Vesce
- BiologyMolecular human reproduction
This study suggests the use of HTR-8/SVneo cells as a suitable model for trophoblast vitamin C transport investigation, and confirms SVCT2 mRNA expression in human first-trimester chorionic villi but not in term placental tissue.