• Publications
  • Influence
Characterization of inhalation aerosols: a critical evaluation of cascade impactor analysis and laser diffraction technique.
Cascade impactor analysis is the standard technique for in vitro characterization of aerosol clouds generated by medical aerosol generators. One important reason for using this inertial separationExpand
  • 127
  • 11
  • PDF
Technological and practical challenges of dry powder inhalers and formulations.
In the 50 years following the introduction of the first dry powder inhaler to the market, several developments have occurred. Expand
  • 179
  • 8
  • PDF
A comparison between spray drying and spray freeze drying to produce an influenza subunit vaccine powder for inhalation.
The aim of this study was to investigate two different processes to produce a stable influenza subunit vaccine powder for pulmonary immunization i.e. spray drying (SD) and spray freeze drying (SFD).Expand
  • 134
  • 5
The clinical relevance of dry powder inhaler performance for drug delivery.
BACKGROUND Although understanding of the scientific basis of aerosol therapy with dry powder inhalers (DPIs) has increased, some misconceptions still persist. These include the beliefs that highExpand
  • 74
  • 5
A critical view on lactose-based drug formulation and device studies for dry powder inhalation: which are relevant and what interactions to expect?
A great number of variables are considered relevant to the interfacial forces in adhesive mixtures, but their effects have mostly been investigated individually, without taking account of the influence they may have on each other. Expand
  • 114
  • 4
Dry powder inhalers for pulmonary drug delivery
The pulmonary route is an interesting route for drug administration, both for effective local therapy (asthma, chronic obstructive pulmonary disease or cystic fibrosis) and for the systemicExpand
  • 205
  • 3
  • PDF
Air classifier technology (ACT) in dry powder inhalation. Part 1. Introduction of a novel force distribution concept (FDC) explaining the performance of a basic air classifier on adhesive mixtures.
Air classifier technology (ACT) is introduced as part of formulation integrated dry powder inhaler development (FIDPI) to optimise the de-agglomeration of inhalation powders. Carrier retention andExpand
  • 109
  • 3
  • PDF
A review of the technical aspects of drug nebulization
Nebulizers are widely used for the inhalation of drug solutions in a variety of respiratory diseases. The efficacy of nebulizer therapy is influenced by a great number of factors, including theExpand
  • 108
  • 3
Dry powder inhalation: past, present and future
ABSTRACT Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficientExpand
  • 73
  • 3
  • PDF
Design and application of a new modular adapter for laser diffraction characterization of inhalation aerosols.
An inhaler adapter has been designed for the characterization of the aerosol clouds from medical aerosol generators such as nebulizers, dry powder inhalers (dpis) and metered dose inhalers (mdis)Expand
  • 51
  • 3