• Publications
  • Influence
Topology of the conceptual network of language.
We define two words in a language to be connected if they express similar concepts. The network of connections among the many thousands of words that make up a language is important not only for theExpand
  • 281
  • 15
The dynamics of genome replication using deep sequencing
Eukaryotic genomes are replicated from multiple DNA replication origins. We present complementary deep sequencing approaches to measure origin location and activity in Saccharomyces cerevisiae.Expand
  • 98
  • 6
Mathematical modelling of whole chromosome replication
All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins. Here weExpand
  • 77
  • 5
Integrated stress response of Escherichia coli to methylglyoxal: transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I
Methylglyoxal (MG) elicits activation of K+ efflux systems to protect cells against the toxicity of the electrophile. ChIP-chip targeting RNA polymerase, supported by a range of other biochemicalExpand
  • 24
  • 4
Optimal placement of origins for DNA replication.
DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, calledExpand
  • 13
  • 2
Onset of chaotic advection in open flows.
In this paper we investigate the transition to chaos in the motion of particles advected by open flows with obstacles. By means of a topological argument, we show that the separation points on theExpand
  • 11
  • 2
Combinatorial stresses kill pathogenic Candida species
Pathogenic microbes exist in dynamic niches and have evolved robust adaptive responses to promote survival in their hosts. The major fungal pathogens of humans, Candida albicans and Candida glabrata,Expand
  • 67
  • 1
Stochastic association of neighboring replicons creates replication factories in budding yeast
Single-cell analyses in budding yeast reveal that neighboring replicons are assembled stochastically and stay associated to maintain stable replication factories.
  • 36
  • 1
Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans
The major fungal pathogen of humans, Candida albicans, mounts robust responses to oxidative stress that are critical for its virulence. These responses counteract the reactive oxygen species (ROS)Expand
  • 29
  • 1
Dynamics of DNA replication in yeast.
We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated.Expand
  • 25
  • 1