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Induction of Oral Tolerance to Oxidized Low-Density Lipoprotein Ameliorates Atherosclerosis
Background— Oxidation of low-density lipoprotein (LDL) and the subsequent processing of oxidized LDL (oxLDL) by macrophages results in activation of specific T cells, which contributes to theExpand
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Blockade of Interleukin-12 Function by Protein Vaccination Attenuates Atherosclerosis
Background—Interleukin-12 (IL-12) has been identified as a key inducer of a type 1 T-helper cell cytokine pattern, which is thought to contribute to the development of atherosclerosis. We sought toExpand
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Effect of natural killer T cell activation on the initiation of atherosclerosis.
It has been shown that natural killer T (NKT) cell activation accelerates atherosclerosis in apoE(-/-) mice. ApoE is, however, an important mediator in the presentation of lipids which may complicateExpand
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Delivery of Chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in LDLr-/- mice.
OBJECTIVE The role of Chlamydia pneumoniae in atherosclerosis is still debated. In this study a novel mouse model was applied to determine the direct impact of C. pneumoniae on the arterial wall andExpand
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Vaccination against TIE2 reduces atherosclerosis.
BACKGROUND TIE2(+) cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore, the specific deletion of TIE2(+) cells by means of DNA vaccination mayExpand
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Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis.
OBJECTIVE Vascular endothelial growth factor receptor 2 (VEGFR2)-overexpressing cells may form an interesting target for the treatment of atherosclerosis because of their involvement in processesExpand
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HIV Entry Inhibitor TAK-779 Attenuates Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice
Objective—HIV combination therapy using protease inhibitors is associated with elevated plasma levels of atherogenic lipoproteins and increased risk for atherosclerosis. We investigated whether theExpand
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Vaccination Against VEGFR2 Attenuates Initiation and Progression of Atherosclerosis
Objective—Vascular endothelial growth factor receptor 2 (VEGFR2)–overexpressing cells may form an interesting target for the treatment of atherosclerosis because of their involvement in processesExpand
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Immunomodulation of the inflammatory response in atherosclerosis
Purpose of review Cardiovascular disease, as manifested in the formation of atherosclerotic lesions, can be described as a chronic inflammatory autoimmune-like disease that proceeds in the context ofExpand
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Targeting of peptides to restenotic vascular smooth muscle cells using phage display in vitro and in vivo.
Restenosis after angioplasty occurs in 30-40% of the treated patients. To develop a strategy to deliver drugs to restenotic lesions, we selected phages that bind to proliferating vascular smoothExpand
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