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Motor Skills Training Enhances Lesion-Induced Structural Plasticity in the Motor Cortex of Adult Rats
To assess behavioral experience effects on synaptic plasticity after brain damage, the present study examined the effects of complex motor skills training (the acrobatic task) on synaptic changes inExpand
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Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth
Lung cancer is the leading cause of cancer death worldwide. Recent data suggest that tumor-associated inflammatory cells may modify lung tumor growth and invasiveness. To determine the role ofExpand
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G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood.
Neutrophils are released from the bone marrow in a regulated fashion to maintain homeostatic levels in the blood and to respond to physiological stresses, including infection. We show that underExpand
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Tumor-associated neutrophils: new targets for cancer therapy.
Studies have begun to emerge showing critical roles for neutrophils in tumorigenesis. Neutrophils can have a significant impact on the tumor microenvironment via their production of cytokines andExpand
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Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein‐1‐dependent fashion
There is accumulating evidence that delivery of bone marrow cells to sites of ischemia by direct local injection or mobilization into the blood can stimulate angiogenesis. This has stimulatedExpand
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Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential.
Shwachman-Diamond syndrome (SDS) is a rare multisystem disorder characterized by exocrine pancreatic insufficiency, multilineage hematopoietic dysfunction, and metaphyseal chondrodysplasia. BoneExpand
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Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
Granulocyte colony-stimulating factor (G-CSF) regulates the production, maturation, and function of neutrophils. Its expression is often induced during infection, resulting in high concentrations ofExpand
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Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis
IPF is a progressive lung disorder characterized by fibroblast proliferation and myofibroblast differentiation. Although neutrophil accumulation within IPF lungs has been negatively correlated withExpand
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Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells*
Background: Neutrophil elastase (NE)-induced tumor cell proliferation requires endosomal entry of the proteinase. Results: NE and CG bind to the surface of cancer cells and enter into tumor endosomesExpand
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Systemic levels of G‐CSF and interleukin‐6 determine the angiogenic potential of bone marrow resident monocytes
There is considerable interest in the potential of cell‐based approaches to mediate therapeutic angiogenesis for acute and chronic vascular syndromes. Using a mouse model of HLI, we showed previouslyExpand
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