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Analysis of multiple endocrine disruptors in environmental waters via wide-spectrum solid-phase extraction and dual-polarity ionization LC-ion trap-MS/MS.
An analytical method for the determination of 35 endocrine disrupting chemicals (EDCs) present in the aquatic environment was developed and validated and stability experiments showed no significant loss or deterioration for any of the analytes.
Determination of reference method values by isotope dilution-gas chromatography/mass spectrometry: a five years' experience of two European Reference Laboratories.
- L. Thienpont, B. Van Nieuwenhove, D. Stöckl, H. Reinauer, A. D. De leenheer
- MedicineEuropean journal of clinical chemistry and…
- 1 October 1996
Data demonstrate that current reference methodology is able to guarantee a stable level of high quality of performance, and that reference laboratories of today are capable of providing, in due time, adequate service in the framework of accuracy-based harmonization of methods in routine laboratory medicine.
Evaluation of automated single mass spectrometry to tandem mass spectrometry function switching for comprehensive drug profiling analysis using a quadrupole time-of-flight mass spectrometer.
- T. Decaestecker, K. Clauwaert, A. D. De leenheer
- ChemistryRapid communications in mass spectrometry : RCM
- 15 October 2000
A liquid chromatographic mass spectrometric strategy for systematic toxicological analysis (STA) is presented using the automatic 'on-the-fly' single mass spectrometry mode to tandem mass…
Heroin impurity profiling: trends throughout a decade of experimenting.
Countering matrix effects in environmental liquid chromatography-electrospray ionization tandem mass spectrometry water analysis for endocrine disrupting chemicals.
Metabolism of minocycline in humans.
- H. Nelis, A. D. De leenheer
- Biology, ChemistryDrug metabolism and disposition: the biological…
- 1 March 1982
It is demonstrated that minocycline is the first tetracycline to be metabolized in man, and the principal metabolite was tentatively identified as 9-hydroxyminocyCline by mass spectral and spectrophotometric analysis and comparison with a synthetic compound.
Pitfalls associated with liquid chromatography/electrospray tandem mass spectrometry in quantitative bioanalysis of drugs of abuse in saliva.
Sensitive gas chromatographic--mass spectrometric screening of acetylated benzodiazepines.
Measurement of alpha-, beta-, and gamma tocopherol in serum by liquid chromatography.
A liquid-chromatographic assay for alpha, beta, and gamma-isomeric tocopherols in human serum is reported, finding the smallest injected amount detectable is estimated to be 0.03 micrograms for alpha-, and 0.04 microgramS for beta- and Gamma-tocopherol.
Fatality due to combined use of the designer drugs MDMA and PMA: a distribution study.
The medico-legal findings were compatible with a disseminated intravascular coagulation induced by hyperthermia caused by the simultaneous intake of the amphetamine analogues.