Chromosome-specific recombinant DNA libraries from the fungus Aspergillus nidulans.
- H. Brody, J. Griffith, A. Cuticchia, J. Arnold, W. Timberlake
- BiologyNucleic Acids Research
- 11 June 1991
To simplify the analysis required to determine which clones in a genomic library overlap one another, Aspergillus nidulans cosmid libraries were partitioned into chromosome-specific subcollections and a sufficient number of clones was obtained to predict the overlap and assembly of individual clones into a limited number of contiguous regions.
Detection of aneuploidy for chromosomes 4, 6, 7, 8, 9, 10, 11, 12, 13, 17, 18, 21, X and Y by fluorescence in-situ hybridization in spermatozoa from nine patients with oligoasthenoteratozoospermia…
The cytogenetic data show significantly elevated frequencies of diploidy, autosomal disomy and nullisomy, sex chromosome aneuploidsy, and total aneuPLoidy in OAT patients, which may contribute to the patients' infertility.
TM Finder: A prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales
The hydrophobicity threshold requirement enables TM Finder to distinguish reliably between membrane proteins and globular proteins, thereby adding an important dimension to the program.
The GDB Human Genome Data Base anno 1994.
Three themes described here are dominant in the future plans and represent the essence of the major changes made in the past year of GDB: enhanced data acquisition, better map representation, and full integration into the collection of genomic databases.
Future vision of the GDB Human Genome Database
- A. Cuticchia
- BiologyHuman Mutation
- 1 January 2000
GDB looks to provide a mechanism to link gene‐related information to the human reference sequence and plans to establish federated linkages with “boutique” databases around the world that could contain enormous amounts of valuable information about specific genes or chromosomes.
Compositional symmetries in complete genomes
This paper analyzes the compositional correlations in the complete genomes and finds correlations between A = T and G = C equimolar frequencies and higher order oligonucleotides.
The cancer translational research informatics platform
- P. McConnell, R. Dash, A. Cuticchia
- Computer ScienceBMC Medical Informatics Decis. Mak.
- 24 December 2008
BackgroundDespite the pressing need for the creation of applications that facilitate the aggregation of clinical and molecular data, most current applications are proprietary and lack the necessary…
Managing all those bytes: the Human Genome Project.
- A. Cuticchia, M. Chipperfield, C. Porter, W. Kearns, P. Pearson
- Computer Science, BiologyScience
- 1 October 1993
The three databases of primary importance to the Human Genome Project each store a different kind of information - DNA sequences, chromosome mapping information, and protein sequence and structure - which requires a seamless integration into a single virtual database.
Influence of intercodon and base frequencies on codon usage in filarial parasites.
It is concluded that sequence bias is a genetic characteristic, which is associated with multiple filarial genera, which was observed among the nematode species examined.
ODS: ordering DNA sequences - a physical mapping algorithm based on simulated annealing
The program ODS is very general in the types of data that can be utilized for chromosome reconstruction, such as hybridized synthetic oligonucleotides, restriction endonuclease recognition sites or single copy landmarks, can be used for analysis.