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Chronic Morphine Treatment Modulates the Extracellular Levels of Endogenous Enkephalins in Rat Brain Structures Involved in Opiate Dependence: A Microdialysis Study
- M. M. Nieto, J. Wilson, A. Cupo, B. Roques, F. Noble
- Medicine, Biology
- The Journal of Neuroscience
- 1 February 2002
The endogenous opioid system is often assumed to play a role in vulnerability to drug abuse. However, controversial results have been reported regarding the levels of enkephalins or preproenkephalin… Expand
Ultrastructural study of delta-opioid receptors in the dorsal horn of the rat spinal cord using monoclonal anti-idiotypic antibodies.
The ultrastructural localization of delta-opioid receptors was studied using monoclonal anti-idiotypic antibody prepared with an anti-D-Ala2-D-Leu5-enkephalin. Immunocytochemical techniques were used… Expand
Quantitation and localization of Met-enkephalin-Arg-Gly-Leu in rat brain using highly sensitive antibodies
Met-enkephalin-Arg-Gly-Leu is an endogenous opioid peptide recently identified in bovine adrenal medulla. In the present study, we describe the production of highly sensitive and specific antibodies… Expand
Peripheral stimulation of CCK-B receptors by BC264 induces a hyperexploration, dependent on the ∂ opioid system in the nucleus accumbens of rat
This study analyses the influence of the CCKergic system on the enkephalinergic system in the exploratory behavior of rats, using both behavioral and biochemical approaches. The results show that the… Expand
Subcellular distribution of δ-opioid receptors in the rat spinal cord: an approach using a three-dimensional reconstruction of confocal series of immunolabelled neurons
Using a specific rat monoclonal anti-idiotypic antibody we have examined the subcellular distribution of -opioid receptors in various neuronal subtypes of the rat spinal cord. The immunofluorescence… Expand
[Production of enkephalins by the human and bovine corpus luteum].
In search of early pregnancy factors, we detected by radioimmunoassay the presence of enkephalin in bovine and human corpus luteum. In vitro met-enkephalin release by bovine corpus luteum is about… Expand
Reassessment of opioid binding sites in the rat brain
Opioid binding sites have been characterized pharmacologically in membranes from different areas of the rat brain. Delta, mu and sites belonging to the kappa family (K1, K2, K3) have been detected.… Expand
Enkephalin-like immunoreactive principal ganglion cells and nerve fibres in the inferior mesenteric ganglion of the cat
The occurrence and distribution of methionine-enkephalin (ME), leucine-enkephalin (LE) and methionine-enkephalin-Arg6-Gly7-Leu8 (MERGL)-like (LI) immunoreactive material in the inferior mesenteric… Expand
Enhancement of excretion across locust malpighian tubules by a diuretic vasopressin-like hormone.
Abstract Haemolymph volume of 20-day-old adult locusts was measured in vivo using a dye dilution method. It is close to 200 μl. The rate of dye excretion in vivo by Malpighian tubules exhibited an… Expand
Influence of acute, subchronic and chronic treatment with neuroleptic (haloperidol) on enkephalins and their precursors in the striatum of rat brain
We examined the effects of chronic, subchronic and acute treatment with haloperidol on the ME, the MERGL and enkephalin precursor concentrations in rat brain. The changes affected primarily the… Expand