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Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.
TLDR
It is shown that PRC2 activity is not only associated with H3K27me3 but also regulates all forms of H3k27 methylation in a spatially defined manner, contributing to different genomic functions in mouse embryonic stem cells. Expand
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.
TLDR
It is shown at a genome-wide level that Ogt preferentially associates with Tet1 to genes promoters in close proximity of CpG-rich transcription start sites, suggesting a link between Tet1 and Ogt activities in regulating C pG island methylation. Expand
Threshold-controlled ubiquitination of the EGFR directs receptor fate
TLDR
A nonlinear modality of epidermal growth factor receptor (EGFR)‐activated signal transduction is uncovered, by demonstrating that the ubiquitination of the EGFR at the PM is threshold controlled. Expand
Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.
TLDR
The results considerably extend the number of known in vivo methylation sites and indicate their significant presence on several protein complexes involved at all stages of gene expression, from chromatin remodelling and transcription to splicing and translation. Expand
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth
TLDR
It is shown that CLIC1 exists also as a circulating protein, secreted via extracellular vesicles (EVs) released by either cell lines or GBM-derived CSCs, which is a novel regulator of GBM growth. Expand
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
TLDR
The authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases. Expand
Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation
TLDR
It is shown that CENP-A from Saccharomyces cerevisiae, termed Cse4, is methylated on arginine 37 (R37) and that this methylation regulates the recruitment of kinetochore components to centromeric sequences, identifying a unique regulatory principle on centromer chromatin by posttranslational modification of the amino terminus of CenH3. Expand
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death
TLDR
A new, immune-related mechanism of action of cetuximab that may help to tailor personalized medicine is demonstrated that induces immunogenic cell death (ICD) that activates a potent antitumor response. Expand
Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells
TLDR
It is shown that, in mouse Embryonic Stem cells, YY1 has genome-wide PcG-independent activities while it is still stably associated with the INO80 chromatin-remodeling complex, as well as with novel RNA helicase activities, suggesting a role for YY 1 in regulating small RNA biogenesis. Expand
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity
TLDR
A newly established pipeline coupling stable isotope labeling with amino acids in cell culture (SILAC) with immunoenriched methyl peptides to globally profile arginine monomethylation and symmetric dimethylation after PRMT5 inhibition by a selective inhibitor is used. Expand
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