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Methoxychlor as a model for environmental estrogens.
- A. Cummings
- Biology, Medicine
- Critical reviews in toxicology
- 1 July 1997
Estrogens can have a variety of physiological effects, especially on the reproductive system. Chemicals with estrogenic activity that are present in the environment may thus be considered potentially… Expand
Dioxins and endometriosis: a plausible hypothesis.
A potential connection exists between exposure to organochlorine chemicals and the increasing prevalence of endometriosis. Evidence shows that dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) can… Expand
Induction of endometriosis in mice: a new model sensitive to estrogen.
Endometriosis consists of the growth of endometrial tissue outside the uterus. A rat model of endometriosis is available to evaluate the potential for environmental chemicals to promote the disease… Expand
Promotion of endometriosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats and mice: time-dose dependence and species comparison.
In the disease of endometriosis, endometrial tissue grows outside the uterus, usually in the peritoneal cavity. Rodent models of endometriosis allow a way to reproduce the disease, evaluate effects… Expand
Mode of Action: Inhibition of Androgen Receptor Function—Vinclozolin-Induced Malformations in Reproductive Development
Vinclozolin is a fungicide that has been shown to cause Leydig cell tumors and atrophy of the accessory sex glands in adult rodents. In addition, exposure of rats during pregnancy causes a pattern of… Expand
Effect of atrazine on implantation and early pregnancy in 4 strains of rats.
- A. Cummings, B. Rhodes, R. Cooper
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 November 2000
Atrazine (ATR) is an herbicide that has been shown to have adverse reproductive effects including alterations in levels of pituitary hormones such as prolactin (prl) and luteinizing hormone (LH) in… Expand
Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.
- A. Cummings, J. Hedge, J. Laskey
- Medicine, Biology
- Fundamental and applied toxicology : official…
- 1 December 1997
Ketoconazole (KCZ) is an imidazole antifungal agent that also affects P450 enzymes of the mammalian steroidogenic system. Several steps in the ovarian steroidogenesis pathway are known to be… Expand
Evaluation of the effects of methanol during early pregnancy in the rat.
- A. Cummings
- 24 May 1993
Recent attention to methanol (MeOH) as a potential alternative fuel prompted an evaluation of the chemical's effects during early pregnancy. Rats were dosed by gavage during Days 1-8 of pregnancy at… Expand
Gene–Environment Interactions: A Review of Effects on Reproduction and Development
ABSTRACT Polymorphisms in genes can lead to differences in the level of susceptibility of individuals to potentially adverse effects of environmental influences, such as chemical exposure, on… Expand
Methoxychlor regulates rat uterine estrogen-induced protein.
Methoxychlor (MXC), a proestrogenic pesticide, has adverse effects on fertility and uterine function in rodents. MXC is converted to an estrogenic substance,… Expand