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Geographic distribution of the 20210 G to A prothrombin variant.
A variant in prothrombin (clotting factor II), a G to A transition at nucleotide position 20210, has recently been shown to be associated with the prothrombin plasma levels and the risk of bothExpand
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Relation of arterial pressure with body sodium, body potassium and plasma potassium in essential hypertension.
1. Exchangeable sodium (NaE), plasma electrolytes and arterial pressure were measured in 121 normal subjects and 91 patients with untreated essential hypertension (diastolic greater than 100 mmHg),Expand
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Polymorphism at the Apoprotein‐E locus in relation to risk of coronary disease
The frequency of genotypes at the polymorphic locus which codes for Apoprotein‐E, an important constituent of very low density serum lipoprotein, has been determined in a random sample of personsExpand
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The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic population
We have investigated the prevalence of a recently reported genetic variation in the prothrombin gene (G20210A) in patients with an objectively confirmed history of venous thrombosis. 12/219 patientsExpand
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The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors’ Organization
Summary.  von Willebrand disease (VWD) is the commonest inherited bleeding disorder. However, despite an increasing understanding of the pathophysiology of VWD, the diagnosis of VWD is frequentlyExpand
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An investigation of the von Willebrand factor genotype in UK patients diagnosed to have type 1 von Willebrand disease.
Forty families diagnosed by UK centres to have type 1 VWD were recruited. Following review, six families were re-diagnosed to have type 2 VWD, one to have a platelet storage pool disorder, and oneExpand
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Contribution of APOE promoter polymorphisms to Alzheimer’s disease risk
ObjectiveTo determine whether the effects of APOE promoter polymorphisms on AD are independent of the APOE-&egr;4 allele. BackgroundRecently, the −491 A→T and −219 G→T polymorphisms located in theExpand
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The C677T MTHFR variant and the risk of venous thrombosis.
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The molecular biology of von Willebrand disease.
von Willebrand disease (VWD) is a common autosomally inherited bleeding disorder associated with mucosal or trauma-related bleeding in affected individuals. VWD results from either a quantitative orExpand
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The factor VIII gene intron 1 inversion mutation: prevalence in severe hemophilia A patients in the UK
  • A. Cumming
  • Medicine
  • Journal of thrombosis and haemostasis : JTH
  • 1 January 2004
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