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Liver disease in cystic fibrosis: A prospective study on incidence, risk factors, and outcome
TLDR
LD is a relatively frequent and early complication of CF, whose detection should be focused at the first life decade in patients with history of meconium ileus, male sex, or severe genotype, and whose impact on the clinical course of CF is uncertain.
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Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A prospective study
TLDR
Cirrhotic patients infected with HCV type 1b carry a significantly higher risk of developing HCC than patients infected by other HCV types, and the latter may require a less intensive clinical surveillance for the early detection of neoplasia.
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Predicting Mortality Risk in Patients With Compensated HCV-Induced Cirrhosis: A Long-Term Prospective Study
TLDR
In patients with compensated HCV-induced cirrhosis, the presence of esophageal varices at baseline predicted decompensation and mortality and patients with a MELD score ≤10 at study entry had a prolonged life expectancy.
View on Wolters Kluwer
Comparison of the clinical features and clinical course of antimitochondrial antibody‐positive and ‐negative primary biliary cirrhosis
TLDR
Data from this historical cohort study suggest that the distinct serological features of AMA‐negative PBC are not associated with substantial differences in the clinical spectrum or course of the disease.
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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
TLDR
This work discovers and validate six previously unknown risk loci for PBC and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.
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Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis.
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Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis
TLDR
In PBC, serum cholesterol levels markedly increase with worsening of cholestasis, and decrease in the late disease stages, despite a severe reduction in biliary secretion, which is not associated with an excess risk of cardiovascular disease.
View on BMJ
Pharmacokinetics of anticancer agents in patients with impaired liver function.
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Sustained virologic response prevents the development of esophageal varices in compensated, Child‐Pugh class A hepatitis C virus–induced cirrhosis. A 12‐year prospective follow‐up study
TLDR
In the long term, the achievement of SVR prevents the development of EV in patients with compensated HCV‐induced cirrhosis, and in these patients, endoscopic surveillance can be safely delayed or avoided.
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Parenteral calcitonin for metabolic bone disease associated with primary biliary cirrhosis
TLDR
It is indicated that parenterally administered calcitonin for 6 mo is ineffective in halting bone loss in patients with primary biliary cirrhosis—associated metabolic bone disease, whereas calcium supplementation may have a transient beneficial effect.
View on Wiley
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