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LH pulsatile secretion and testosterone blood levels are influenced by sexual arousal in human males
- S. Stoléru, A. Ennaji, A. Cournot, A. Spira
- Medicine, Psychology
- 31 December 1993
It is indicated that LH pulsatile secretion and T blood levels are influenced by changes in the state of sexual arousal in human males. Expand
Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 188.8.131.52) by acetorphan.
- C. Gros, A. Souque, +4 authors J. Lecomte
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 October 1989
Results indicate that enkephalinase plays a critical role in ANF degradation in vivo and that its inhibition enhances the levels of circulating endogenous ANF, which, in turn, results in diuresis and natriuresis. Expand
Determination and comparison of the pressor effect of tyramine during long‐term moclobemide and tranylcypromine treatment in healthy volunteers
- I. Berlin, R. Zimmer, A. Cournot, C. Payan, A. Pédarriosse, A. Puech
- Clinical pharmacology and therapeutics
- 1 September 1989
Tyramine was mixed with food and ingested in increasing daily doses, during a normal meal, until a systolic blood pressure increase of at least 30 mm Hg was achieved, and the mean tyramine 30 dose with a meal was 2.8 times higher. Expand
Pharmacokinetics of eltoprazine in healthy male subjects after single dose oral and intravenous administration.
- M. Raghoebar, M. Mak, A. Cournot, M. Pistorius, J. van Harten, H. Roseboom
- British journal of clinical pharmacology
- 1 December 1990
The kinetics, safety and tolerability of eltoprazine hydrochloride were studied in an open, cross-over, partially randomised design after single oral (8 mg) and intravenous (3 and 8 mg) doses to 12… Expand
Stereoselective protection of exogenous and endogenous atrial natriuretic factor by enkephalinase inhibitors in mice and humans.
- J. Lecomte, P. Baumer, +7 authors A. Souque
- Chemistry, Medicine
- European journal of pharmacology
- 10 April 1990
Oral administered sinorphan appears to be a promising compound for therapeutic use in cardiovascular and renal diseases in which ANF has been postulated to exert beneficial effects. Expand
Pharmacokinetics of spiramycin in man.
- A. Frydman, Y. Le Roux, +5 authors J. Gaillot
- The Journal of antimicrobial chemotherapy
- 1 July 1988
Spiramycin's kinetics differ in several important respects from erythromycin's, notably the larger volume of distribution of spiramycin which reflects the higher tissue concentration. Expand
Investigation of the direct determination of uranium in plasma and urine by inductively coupled plasma mass spectrometry
Abstract The determination of uranium in urine is used for the control of subjects at occupational risk particularly in the nuclear power industry. As the levels of uranium in the urine and plasma of… Expand
Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study.
- P. Guinot, C. Brambilla, J. Duchier, P. Braquet, B. Bonvoisin, A. Cournot
- 1 November 1987
This is the first study in man demonstrating the efficacy of a specific PAF-acether antagonist on the immediate response to inhaled allergen challenge in asthmatics, and the findings support the possible role of specific PAf-ac ether antagonists in the treatment of asthma. Expand
Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist.
BN 52063 orally inhibited the inflammatory response to a sub-cutaneous injection of PAF-acether 400 ng and was demonstrated to be well tolerated at doses of 20, 40, 80 and 120 mg with no significant side effects. Expand
Effect of Ginkgo biloba extract on microsomal enzyme induction.
- J. Duché, J. Barré, P. Guinot, J. Duchier, A. Cournot, J. Tillement
- International journal of clinical pharmacology…
It is demonstrated that GBE has no effect on the hepatic microsomal drug oxidation system and the half-life of antipyrine was not affected by GBE and placebo treatments. Expand