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A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development.
The Drosophila gene groucho (gro) encodes a transcriptional corepressor that has critical roles in many development processes. In an effort to illuminate the mechanism of Gro-mediated repression, weExpand
Groucho/TLE family proteins and transcriptional repression.
The Drosophila Groucho (Gro) protein is the prototype for a large family of corepressors, examples of which are found in most metazoans. This family includes the human transducin-like Enhancer ofExpand
Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif
We have adopted Drosophila tissue culture cells as a host system for studying the structure and function of mammalian transcription factors. These cells provide an Sp1-deficient background and haveExpand
Transcriptional repression: the long and the short of it.
Gene-specific repression of transcription plays a central role in gene regulation. This is true for the spatial control of gene activity in development, during which boundaries of gene expression areExpand
Synergistic activation by the glutamine-rich domains of human transcription factor Sp1
We have examined the role of protein-protein interactions in modulating the activity of Sp1, a human transcription factor that utilizes glutamine-rich activation domains. These domains may representExpand
Conversion of dorsal from an activator to a repressor by the global corepressor Groucho.
The Dorsal morphogen acts as both an activator and a repressor of transcription in the Drosophila embryo to regulate the expression of dorsal/ventral patterning genes. Circumstantial evidence hasExpand
Genetic and Proteomic Evidence for Roles of Drosophila SUMO in Cell Cycle Control, Ras Signaling, and Early Pattern Formation
SUMO is a protein modifier that is vital for multicellular development. Here we present the first system-wide analysis, combining multiple approaches, to correlate the sumoylated proteome (SUMO-ome)Expand
Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila
RTK/Ras/MAPK signaling pathways play key functions in metazoan development, but how they control expression of downstream genes is not well understood. In Drosophila, it is generally assumed thatExpand
The torso response element binds GAGA and NTF-1/Elf-1, and regulates tailless by relief of repression.
Modulation of transcription factor activity leading to changes in cell behavior (e.g., differentiation versus proliferation) is one of the critical outcomes of receptor tyrosine kinase (RTK)Expand
A Role for Groucho Tetramerization in Transcriptional Repression
ABSTRACT The Drosophila Groucho (Gro) protein is a corepressor required by a number of DNA-binding transcriptional repressors. Comparison of Gro with its homologues in other eukaryotic organismsExpand