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A Point Mutation in a Domain of Gamma Interferon Receptor 1 Provokes Severe Immunodeficiency
TLDR
The findings suggest that a point mutation may be fatal when it affects functionally important domains of the receptor and that the severity is not directly related to a lack of IFN-γ receptor expression.
Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor.
PRIMARY immunodeficiency diseases are a heterogeneous group of disorders resulting from intrinsic defects of the immune system.1 They are frequently associated with repeated bacterial, fungal, or v...
Dry Eye Disease as an Inflammatory Disorder
TLDR
It is demonstrated that a chronic inflammatory response plays a key role in the pathogenesis of human DED and correlations between inflammatory molecules and clinical data suggest that inflammation can be responsible for some of the clinical symptoms and signs.
Diploid expression of human leukocyte antigen class I and class II molecules on spermatozoa and their cyclic inverse correlation with inhibin concentration.
TLDR
Observations could put to an end a disconcerting and long-lasting controversy on the expression/non-expression of HLA antigens on spermatozoa.
Human T-cell activation deficiencies.
A new MICA allele with ten alanine residues in the exon 5 microsatellite.
TLDR
A novel allele with 10 GCT repetitions (A10) which was detected by reference strand mediated conformation analysis and confirmed by DNA sequencing is reported.
In Vitro Simulation of Corneal Epithelium Microenvironment Induces a Corneal Epithelial-like Cell Phenotype from Human Adipose Tissue Mesenchymal Stem Cells
TLDR
It is suggested that hAT-MSCs could provide a novel source of stem cells that hold the potential to restore sight lost in patients suffering from bilateral ocular surface failure due to LSCD by subjecting them to an in vitro microenvironment containing conditioning signals derived from differentiated human corneal epithelial cells.
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