Share This Author
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
- D. Loo, A. Copani, C. Pike, E. R. Whittemore, A. Walencewicz, C. Cotman
- BiologyProceedings of the National Academy of Sciences…
- 1 September 1993
It is reported that synthetic A beta Ps trigger the degeneration of cultured neurons through activation of an apoptotic pathway, suggesting that apoptosis may play a role in the neuronal loss associated with Alzheimer disease.
Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain
It is concluded that induction of DKK1 contributes to the pathological cascade triggered by β-amyloid and is critically involved in the process of tau phosphorylation.
Neuroprotection by Glial Metabotropic Glutamate Receptors Is Mediated by Transforming Growth Factor-β
- V. Bruno, G. Battaglia, G. Casabona, A. Copani, F. Caciagli, F. Nicoletti
- BiologyThe Journal of Neuroscience
- 1 December 1998
It is concluded that a transient activation of group-II mGlu receptors (presumably mGLU3 receptors) in astrocytes leads to an increased formation and release of TGFβ, which in turn protects neighbor neurons against excitotoxic death.
Divide and Die: Cell Cycle Events as Triggers of Nerve Cell Death
For over a decade, evidence has mounted that nerve cell death in the CNS is often intimately linked to a process of cell division. Mitotic markers appear in neurons at risk for death in a variety of…
Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs
- V. Bruno, G. Battaglia, F. Nicoletti
- BiologyJournal of cerebral blood flow and metabolism…
- 1 September 2001
A series of observations suggest a potential application of mGlu5 receptor antagonists in chronic neurodegenerative disorders, such as amyotrophic lateral sclerosis and Alzheimer disease.
β-Amyloid Monomers Are Neuroprotective
Synthetic Aβ1-42 monomers support the survival of developing neurons under conditions of trophic deprivation and protect mature neurons against excitotoxic death, a process that contributes to the overall neurodegeneration associated with AD.
Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain
It is concluded that the efficient mGluR‐mediated polyphosphoinositide hydrolysis in 9‐day‐old rats is mediated by mGLUR5, and the increased expression of mGLuR1 in the adult cerebellum does not substitute for the decline of mgluR5 expression in the ability to mediate polyph phosphoinositid hydrolytic activity.
TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.
Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture.
Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice