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Genome sequence of the Brown Norway rat yields insights into mammalian evolution
This first comprehensive analysis of the genome sequence of the Brown Norway (BN) rat strain is reported, which is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution.
Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
The results show that maintenance of the ovarian phenotype is an active process throughout life and might have important medical implications for the understanding and treatment of some disorders of sexual development in children and premature menopause in women.
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
Characterization of endogenous Nanog and Oct4 protein complexes in mouse ES cells found that these transcription factors interact with each other and associate with proteins from multiple repression complexes, including the NuRD, Sin3A and Pml complexes.
Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development
- Peili Gu, B. Goodwin, +10 authors A. Cooney
- Medicine, BiologyMolecular and Cellular Biology
- 1 May 2005
In vitro and in vivo results show that LRH-1 plays an essential role in the maintenance of Oct4 expression in ES cells at the epiblast stage of embryonic development, thereby maintaining pluripotence at this crucial developmental stage prior to segregation of the primordial germ cell lineage at gastrulation.
Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool
The results show that the mammalian oocyte serves as the headquarters of programming of follicleactivation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth.
Differential Oocyte-Specific Expression of Cre Recombinase Activity in GDF-9-iCre, Zp3cre, and Msx2Cre Transgenic Mice1
Comparison of the ontogeny of the Cre activities of GDF-9-iCre, Zp3Cre, and Msx2Cre transgenic mice shows there is sequential Cre activity of the three transgenes that will allow inactivation of a target gene at different points in folliculogenesis.
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone,…
- A. Cooney, S. Tsai, B. O’Malley, M. Tsai
- Biology, MedicineMolecular and cellular biology
- 1 September 1992
A functional consequence of the promiscuous DNA binding of COUP-TF is its ability to down-regulate hormonal induction of target gene expression by other members of the steroid-thyroid hormone receptor superfamily such as the vitamin D3, thyroid hormone, and retinoic acid receptors.
Orphan Nuclear Receptor GCNF Is Required for the Repression of Pluripotency Genes during Retinoic Acid-Induced Embryonic Stem Cell Differentiation
- Peili Gu, Damien LeMenuet, A. Chung, M. Mancini, D. Wheeler, A. Cooney
- Biology, MedicineMolecular and Cellular Biology
- 1 October 2005
A central role for GCNF is established in the repression of pluripotency gene expression during retinoic acid-induced ES cell differentiation and early mouse embryonic development.
Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome.
The exon structure of the ligand-binding domain suggests that exon shuffling has played a role in the evolution of this family of nuclear receptors, and an invariant splice junction in all members of the NR family except LXRbeta suggests a functional role for the intron.
Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
- D. Adhikari, Wenjing Zheng, +6 authors Kui Liu
- Biology, MedicineHuman molecular genetics
- 20 October 2009
The results suggest that Tsc/mTORC1 signaling and PTEN/PI3K (phosphatidylinositol 3 kinase) signaling synergistically regulate the dormancy and activation of primordial follicles, and together ensure the proper length of female reproductive life.