A. Connelly

Publications333
h-index78
Citations24,163
Highly Influential Citations1,416
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Robust determination of the fibre orientation distribution in diffusion MRI: Non-negativity constrained super-resolved spherical deconvolution
TLDR
The introduction of a constraint on such negative regions is proposed to improve the conditioning of the spherical deconvolution, and this approach is shown to provide FOD estimates that are robust to noise whilst preserving angular resolution.
Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution
TLDR
This study proposes a novel method for estimating the fiber orientation distribution directly from high angular resolution diffusion-weighted MR data without the need for prior assumptions regarding the number of fiber populations present, assuming that all white matter fiber bundles in the brain share identical diffusion characteristics.
MRtrix: Diffusion tractography in crossing fiber regions
TLDR
This methodology is shown to provide superior delineations of a number of known white matter tracts, in a manner robust to crossing fiber effects, and has been compiled into a software package, called MRtrix, which has been made freely available for use by the scientific community.
Differential effects of early hippocampal pathology on episodic and semantic memory.
Global anterograde amnesia is described in three patients with brain injuries that occurred in one case at birth, in another by age 4, and in the third at age 9. Magnetic resonance techniques…
MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation
TLDR
A high-level overview of the features of the MRtrix3 framework and general-purpose image processing applications provided with the software is provided.
Delay and dispersion effects in dynamic susceptibility contrast MRI: Simulations using singular value decomposition
TLDR
Both delay and dispersion were found to introduce significant underestimation of cerebral blood flow (CBF) and overestimation of mean transit time (MTT) in DSC quantification.
Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data
TLDR
The aim of this study is to incorporate support for multi-shell data into the CSD approach as well as to exploit the unique b-value dependencies of the different tissue types to estimate a multi-tissue ODF.
Resolving crossing fibres using constrained spherical deconvolution: Validation using diffusion-weighted imaging phantom data
TLDR
An experimental model of crossing fibres, consisting of water-filled plastic capillaries, is used to thoroughly assess three such techniques: constrained spherical deconvolution (CSD), super-resolved CSD (super-CSD) and Q-ball imaging (QBI).
Apparent Fibre Density: A novel measure for the analysis of diffusion-weighted magnetic resonance images
TLDR
This article presents and evaluates a novel method to modulate the FOD to account for changes in fibre bundle cross-sectional area that occur during spatial normalisation, and describes a novel approach for statistical analysis of AFD that uses cluster-based inference of differences extended throughout space and orientation.
Anatomically-constrained tractography: Improved diffusion MRI streamlines tractography through effective use of anatomical information
TLDR
Results indicate that some of the known false positives associated with tractography algorithms are prevented, such that the biological accuracy of the reconstructions should be improved, provided that state-of-the-art streamlines tractography methods are used.
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