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Light‐sensitive Intelligent Drug Delivery Systems †
In this review, the mechanisms used to develop polymeric micelles, gels, liposomes and nanocomposites with light‐sensitiveness are analyzed and the potential of light‐sensitive carriers as functional components of intelligent DDS is discussed.
Imprinted soft contact lenses as norfloxacin delivery systems.
Results prove that ITC is a useful tool for the optimization of the structure of the imprinted cavities in order to obtain efficient therapeutic soft contact lenses.
Effect of batch variation and source of pulp on the properties of microcrystalline cellulose
Abstract We have investigated the characteristics of three batches of microcrystalline cellulose supplied by the same manufacturer but differing in the manufacturing process employed and/or the type
Poloxamer 407/TPGS Mixed Micelles as Promising Carriers for Cyclosporine Ocular Delivery.
Developing an aqueous micellar formulation for an efficient cyclosporine delivery to the ocular tissues, using a water-soluble derivative of vitamin E and vitamin E succinate from TPGS and poloxamer 407 as excipients demonstrated the capability of mixed micelles to diffuse into the sclera and sustain cyclospora delivery.
Dicalcium phosphate dihydrate and anhydrous dicalcium phosphate for direct compression: A comparative study
Abstract Dicalcium phosphate dihydrate (Emcompress) and anhydrous dicalcium phosphate (Anhydrous Emcompress) for direct compression were compared as regards particle size distribution and flow
Drug-Eluting Intraocular Lenses
Several approaches are under study, namely combination of the IOL with an insert in a single device, soaking in drug solutions, impregnation using supercritical fluids, coating with drug/polymer layers, and covalent grafting of the drug.
Smart drug delivery systems: from fundamentals to the clinic.
A critical overview of therapeutically-interesting stimuli to trigger drug release and the evolution of responsive materials suitable as functional excipients is offered, illustrated with recent examples of formulations in clinical trials or already commercially available, which can provide a perspective on the current state of the art on smart drug delivery systems.
Solubilization and stabilization of camptothecin in micellar solutions of pluronic-g-poly(acrylic acid) copolymers.
The capability of a family of copolymers comprising Pluronic (PEO-PPO-PEO) surfactants covalently conjugated with poly(acrylic acid) (Pluronic-PAA) to enhance the aqueous solubility and stability of
Chemically cross-linked and grafted cyclodextrin hydrogels: from nanostructures to drug-eluting medical devices.
The present review focuses on the approaches tested to synthesize nano- to macro-size covalently cross-linked CD networks and the advantages of having the CDs chemically bound among themselves and to substrates are provided and their applicability in therapeutics discussed.
Soft contact lenses capable of sustained delivery of timolol.
The results indicate that the incorporation of MAA as comonomer increases the timolol loading capacity to therapeutically useful levels while retaining appropriate release characteristics.