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Genetic immunization against neu /erbB2 transgenic breast cancer
Abstract erbB2/neu, an overexpressed oncogene product, has been proposed as a human cancer vaccine target. In the present study, transgenic (rat neuNT oncogene) FVB/neu mice, developingExpand
Autoantibody to p185erbB2/neu oncoprotein by vaccination with xenogenic DNA
Abstract The passive transfer of antibodies and vaccination procedures against p185, the erbB2/neu oncoprotein, are approaches being explored for treatment of human breast cancer. We now report theExpand
Protease inhibitors from the parasitic worm Parascaris equorum.
Two proteic inhibitors (I and II) of serine proteases have been purified from the parasitic worm Parascaris equorum by affinity chromatography on immobilized trypsin followed by preparativeExpand
Superoxide dismutase in red blood cells: method of assay and enzyme content in normal subjects and in patients with beta-thalassemia (major and intermedia).
The applicability to red blood cells of two widely used methods for spectrophotometric assay of superoxide dismutase activity has been tested, in view of the demand for routine screening of the levelExpand
The ciliate Euplotes raikovi heterozygous at the mat genetic locus coreleases two individual species of mating pheromone: Genetic and biochemical evidence.
Euplotes raikovi of the wild-type strain 13 was found to be heterozygous (mat-1/mat-2) for the genetic locus mat, which is supposed to control the mating-type specificity of freely released matingExpand
Prognostic relevance of altered Fas (CD95)‐system in human breast cancer
The Fas ligand (FasL) and its receptor Fas (APO‐1 or CD95) are members, respectively, of the tumor necrosis factor family that, upon interaction with each other, play a key role in the initiation ofExpand
Purification to apparent homogeneity of the mating pheromone of mat-1 homozygous Euplotes raikovi.
Mating type-specific mating pheromones autonomously released into the environment control cell-cell union in conjugation of the marine ciliate Euplotes raikovi. The mating pheromone, termed euplomoneExpand
Purification and characterization of new mating pheromones of the ciliate Euplotes raikovi.
Cell union in mating pairs in the ciliate Euplotes raikovi is controlled by a system of multiple mating types which are inherited with alleles codominant at the genetic locus mat and expressed viaExpand
Isolation of the mating-inducing factor of the ciliate Euplotes.
Numerous strains of different mating types of the marine ciliate Euplotes raikovi have been found to be autonomous excreters into the surrounding medium of specific mating-inducing factors (gamones)Expand
Ligand-dependent behavior of the hemoglobin from the ascarid Parascaris equorum
Abstract Hemoglobin from the ascarid Parascaris equorum is made of eight identical subunits, each containing protoheme as a prosthetic group. The thermodynamic and kinetic properties of the bindingExpand