Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
- W. Mcdonald, A. Compston, +13 authors J. Wolinsky
- Medicine
- Annals of neurology
- 1 July 2001
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and… Expand
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
- P. Burton, D. Clayton, +193 authors A. Compston
- Biology, Medicine
- Nature
- 7 June 2007
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study… Expand
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
- P. D. Jager, Xiaoming Jia, +30 authors J. Oksenberg
- Biology, Medicine
- Nature Genetics
- 1 July 2009
We report the results of a meta-analysis of genome-wide association scans for multiple sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. Replication in an… Expand
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
- A. Beecham, N. Patsopoulos, +190 authors J. McCauley
- Medicine, Biology
- Nature Genetics
- 29 September 2013
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated… Expand
McAlpine's Multiple Sclerosis
- A. Compston
- Medicine
- 2005
SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS 1. The story of multiple sclerosis The evolving concept of multiple sclerosis Naming and classifying the disease: 1868-1983 Clinical descriptions of… Expand
- 470
- 14
The role of the CD58 locus in multiple sclerosis
- P. De Jager, C. Baecher-Allan, +35 authors D. Hafler
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 31 March 2009
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with demyelination and axonal loss. A whole genome association scan suggested that allelic variants in the… Expand
Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis
- A. Coles, M. Wing, S. Smith, F. Coraddu, A. Compston
- Medicine
- The Lancet
- 13 November 1999
BACKGROUND
Multiple sclerosis results from T-cell-dependent inflammatory demyelination of the central nervous system. Our objective was long-term suppression of inflammation with short-term… Expand
Bayesian refinement of association signals for 14 loci in 3 common diseases
- J. Maller, G. McVean, +34 authors P. Donnelly
- Medicine, Biology
- Nature Genetics
- 1 December 2012
To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases:… Expand
A second major histocompatibility complex susceptibility locus for multiple sclerosis
- T. W. Yeo, P. D. De Jager, +27 authors S. Sawcer
- Medicine, Biology
- Annals of neurology
- 1 March 2007
Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA‐DRB1 gene in… Expand
Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
- A. Coles, M. Wing, +6 authors A. Compston
- Medicine
- 1 September 1999
The elective treatment of patients with multiple sclerosis, using a humanized anti‐leukocyte (CD52) monoclonal antibody (Campath‐1H), has illuminated mechanisms that underlie the clinical course of… Expand