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Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time andExpand
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA studyExpand
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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
We report the results of a meta-analysis of genome-wide association scans for multiple sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. Replication in anExpand
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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associatedExpand
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McAlpine's Multiple Sclerosis
SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS 1. The story of multiple sclerosis The evolving concept of multiple sclerosis Naming and classifying the disease: 1868-1983 Clinical descriptions ofExpand
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The role of the CD58 locus in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with demyelination and axonal loss. A whole genome association scan suggested that allelic variants in theExpand
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Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis
BACKGROUND Multiple sclerosis results from T-cell-dependent inflammatory demyelination of the central nervous system. Our objective was long-term suppression of inflammation with short-termExpand
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Bayesian refinement of association signals for 14 loci in 3 common diseases
To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases:Expand
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A second major histocompatibility complex susceptibility locus for multiple sclerosis
Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA‐DRB1 gene inExpand
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Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
The elective treatment of patients with multiple sclerosis, using a humanized anti‐leukocyte (CD52) monoclonal antibody (Campath‐1H), has illuminated mechanisms that underlie the clinical course ofExpand
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