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1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4.
- Alexander L. Ruchelman, H. Man, +9 authors G. Muller
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 November 2011
A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and phosphodiesterase 4 (PDE4). By using the… Expand