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1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4.
A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and phosphodiesterase 4 (PDE4). By using theExpand
Preclinical antitumor activity of benzopyranones
TLDR
These studies demonstrate that CC-8490 and its close analogs have potent in vitro and in vivo anticancer activity against a variety of human cancer models. Expand