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Systemic complications of acromegaly: epidemiology, pathogenesis, and management.
TLDR
The most important cause of morbidity and functional disability of this disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years.
Advances in the treatment of prolactinomas.
TLDR
A critical analysis of the efficacy and safety of the various modes of therapy available for the treatment of patients with prolactinomas with an emphasis on challenging situations is provided, a discussion of the data regarding withdrawal of medical therapy, and a foreshadowing of novel approaches to therapy that may become available in the future.
Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure.
TLDR
In conclusion, patients with Cushing's disease still have increased cardiovascular risk and suffer from premature atherosclerosis once cured, and patients was probably due to residual abdominal a long term period of WHR, which was inversely correlated to the duration of CD.
Growth hormone and the heart
TLDR
Several lines of evidence have suggested that the cardiovascular abnormalities can be partially reversed by suppressing GH and IGF‐I levels in acromegaly or after GH replacement therapy in GHD patients.
Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: a 24-week pilot study.
TLDR
Both SET and diet interventions improve fertility in obese PCOS patients with anovulatory infertility, and it is hypothesized that in both interventions an improvement in insulin sensitivity is the pivotal factor involved in the restoration of ovarian function but potentially acting through different mechanisms.
Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese
TLDR
Six-month metformin administration is significantly more effective than six-cycle CC treatment in improving fertility in anovulatory nonobese PCOS women.
Nutritional recommendations for CoVID-19 quarantine
TLDR
Quarantinerelated stress also results in sleep disturbances that in turn further worsen the stress and increase food intake thus giving rise to a dangerous vicious cycle, so it is important to consume food containing or promoting the synthesis of serotonin and melatonin at dinner.
Clinical characterization of familial isolated pituitary adenomas.
TLDR
Homogeneous and heterogeneous expression of prolactinomas, somatotropinoma, NS, and Cushing's disease can occur within families in the absence of MEN1/CNC.
Vitamin D and Cancer
TLDR
The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing several mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer.
Resistance to somatostatin analogs in acromegaly.
TLDR
Predictors of response are patients' gender, age, initial GH and IGF-I levels, and tumor mass, as well as adequate expression of somatostatin receptor types 2 and 5, those with the highest affinity for octreotide and lanreotide.
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