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Direct comparison of B-type natriuretic peptide (BNP) and amino-terminal proBNP in a large population of patients with chronic and symptomatic heart failure: the Valsartan Heart Failure (Val-HeFT)
BACKGROUND The B-type or brain natriuretic peptides (BNP) and the amino-terminal probrain natriuretic peptide (NT-proBNP) are good markers of prognosis and diagnosis in chronic heart failure (HF). ItExpand
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Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications.
The discovery of cardiac natriuretic hormones required a profound revision of the concept of heart function. The heart should no longer be considered only as a pump but rather as a multifunctionalExpand
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Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: a review.
BACKGROUND The pathophysiologic and clinical relevance of cardiac natriuretic hormone (CNH) assays has been investigated in numerous experimental and clinical studies. Authors have sought to evaluateExpand
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Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure.
OBJECTIVES We sought to evaluate the effect of physical training on neurohormonal activation in patients with heart failure (HF). BACKGROUND Patients with HF benefit from physical training. ChronicExpand
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Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences
Abstract Acute kidney injury (AKI) is a common and serious condition, currently diagnosed by functional biomarkers, such as serum creatinine measurements. Unfortunately, creatinine increase is aExpand
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Evidence for DNA damage in patients with coronary artery disease.
According to the "monoclonal hypothesis" of atherosclerosis, several studies suggest that cancer and atherosclerosis may have several fundamental biological mechanisms in common. Therefore, anExpand
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Pathophysiologic relevance of measuring the plasma levels of cardiac natriuretic peptide hormones in humans.
Cardiac natriuretic peptides (ANP, BNP, and biologically active peptides of the N-terminal proANP1-98) are differently regulated in their production/secretion patterns and clearance rates;Expand
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Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones.
Thirty years ago, De Bold et al. (20) reported that atrial extracts contain some biologically active peptides, which promote a rapid and massive diuresis and natriuresis when injected in rats. It isExpand
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Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease
Abstract. Elevated levels of plasma homocysteine (Hcy), a risk factor for coronary artery disease (CAD), can result from genetic errors, e.g., the methylenetetrahydrofolate reductase (MTHFR)Expand
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Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease.
Recent evidence suggests that somatic mutations in nuclear and mitochondrial DNA accumulated during aging, may significantly contribute to the pathogenesis of chronic-degenerative illness such asExpand
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