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A General Model of Prion Strains and Their Pathogenicity
Recent advances suggest that prions themselves are not directly neurotoxic, but rather their propagation involves production of toxic species, which may be uncoupled from infectivity. Expand
Ecology and behavior of first instar larval Lepidoptera.
Experimental and manipulative studies are vital for an understanding of theories linking female oviposition behavior with larval survival, plant defense theory, and population dynamics, as well as modern crop resistance breeding programs. Expand
Prion protein is necessary for normal synaptic function
It is argued that loss of function of PrPc may contribute to the early synaptic loss3 and neuronal degeneration seen in Creutzfeldt–Jakob disease and scrapie and bovine spongiform encephalopathy in animals. Expand
Invasive phytophagous pests arising through a recent tropical evolutionary radiation: the Bactrocera dorsalis complex of fruit flies.
The Bactrocera dorsalis complex of tropical fruit flies contains 75 described species, largely endemic to Southeast Asia, and development of a phylogeny of the group is considered a high priority to provide a framework for future evolutionary and ecological studies. Expand
High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds.
- S. Luckett, R. S. Garcia, +4 authors R. L. Brady
- Biology, Medicine
- Journal of molecular biology
- 9 July 1999
This study helps delineate the minimal unit required for effective peptide inhibitors of serine proteinases, and will assist in the further design of inhibitors to this widespread class of enzymes. Expand
Biotic indirect effects: a neglected concept in invasion biology
The evidence for the occurrence of four of the most commonly documented indirect effects (apparent competition, indirect mutualism/commensalism, exploitative competition, and trophic cascades) in the invasion process is examined. Expand
Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites
- D. B. Freir, Andrew J. Nicoll, +11 authors J. Collinge
- Biology, Medicine
- Nature communications
- 1 June 2011
It is shown that PrP is required for the plasticity-impairing effects of ex vivo material from human AD brain and that standardized Aβ-derived diffusible ligand (ADDL) preparations disrupt hippocampal synaptic plasticity in a PrP-dependent manner. Expand
Location and properties of metal-binding sites on the human prion protein
- G. Jackson, I. Murray, +4 authors J. Collinge
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 3 July 2001
Two high-affinity binding sites for divalent transition metals within the human prion protein are characterized and a previously unreported second site around histidines 96 and 111 is revealed, a region of the molecule known to be crucial for prion propagation. Expand
The ecology of Bactrocera tryoni (Diptera: Tephritidae): what do we know to assist pest management?
It is concluded that there are major gaps in the knowledge required to implement most noninsecticide-based management approaches, and priority areas for future research include host–plant interactions, protein and cue-lure foraging and use, spatial dynamics, development of new monitoring tools and better integration of fruit flies into general horticultural IPM systems. Expand
Disease-associated prion protein oligomers inhibit the 26S proteasome.
Evidence for a direct relationship between prion neuropathology and impairment of the ubiquitin-proteasome system (UPS) in prion-infected UPS-reporter mice is presented and a mechanism for intracellular neurotoxicity mediated by oligomers of misfolded prion protein is suggested. Expand