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Exenatide versus glibenclamide in patients with diabetes.
TLDR
Both exenatide and glibenclamide gave a similar improvement of glycemic control, but only exen atide gave improvements of insulin resistance and beta-cell function, giving also a decrease of body weight and of inflammatory state.
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Metformin and its clinical use: new insights for an old drug in clinical practice
TLDR
If metformin use during pregnancy and the lactation period is supported by few data, it could be indicated for women with polycystic ovary syndrome, since it could diminish circulating androgens and insulin resistance, thus ameliorating the ovulation rate.
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Matrix metalloproteinase-2 and -9 levels in obese patients.
TLDR
Plasma levels of M MP-2 and MMP-9 are increased in obese patients which may reflect abnormal ECM metabolism, and these levels were significantly higher in obese group.
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Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects.
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Different Effect of Psyllium and Guar Dietary Supplementation on Blood Pressure Control in Hypertensive Overweight Patients: A Six-Month, Randomized Clinical Trial
TLDR
Six-month supplementation with psyllium fiber, but not with guar fiber nor standard diet, appears to significantly reduce both SBP and DBP in hypertensive overweight subjects.
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Immune modulation by curcumin: The role of interleukin-10
TLDR
In vitro and in pre-clinical models curcumin is able to modulate the disease pathophysiology of conditions such as pain and neurodegenerative diseases, bowel inflammation, and allergy, but also of infections and cancer through its effect on IL-10 secretion.
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Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or…
TLDR
LTPs positively influenced the office SBP, PWV, SV, SV index, ACI and VI in patients with high-normal BP or first-degree hypertension in a prospective double-blind randomized clinical trial.
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RICE BRAN AND ITS MAIN COMPONENTS: POTENTIAL ROLE IN THE MANAGEMENT OF CORONARY RISK FACTORS
TLDR
The main aim of this paper is to review the available data on pharmacology and toxicology of rice bran and its main components with a particular attention to those data suggesting a potential efficacy in reducing the cardiovascular disease risk.
Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects
TLDR
It is demonstrated that a 10 mg monacolin nutraceutical treatment appears to safely reduce cholesterolemia, hs-CRP, and markers of vascular remodeling in moderately hypercholesterolemic subjects, and results need to be confirmed in larger patient samples and in studies with longer duration.
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Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel
TLDR
The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who have not achieved lipid goals, and patients with statin intolerance.
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