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Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation.
TLDR
It is concluded that virus-induced HC is a frequent complication after allogeneic hematopoietic cell transplantation and treatment with cidofovir is feasible, and further studies are warranted to evaluate its activity in HC mediated by BKV or JCV.
A randomized comparison of two prophylaxis regimens and a paired comparison of on-demand and prophylaxis treatments in hemophilia A management
TLDR
The present study demonstrates comparable safety and effectiveness for two prophylaxis regimens and that prophyllaxis significantly reduces bleeding compared with on‐demand treatment and offers an alternative to standard proPHylaxis for the prevention of bleeding.
Immune reconstitution after haematopoietic cell transplantation in children: immunophenotype analysis with regard to factors affecting the speed of recovery
TLDR
The results demonstrated that T‐cell recovery was severely impaired in children after autologous HCT, and it should be emphasized that specific approaches to enhance immune reconstitution are necessary to control minimal residual disease and avoid the risk of infectious complications in the autOLOGous setting.
Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study
TLDR
It is indicated that HSCT following a myeloablative preparative regimen offers a high probability of survival for children with advanced MDS and the risk of relapse increased with more advanced disease.
Treosulfan-based preparative regimens for allo-HSCT in childhood hematological malignancies: a retrospective study on behalf of the EBMT pediatric diseases working party
TLDR
Children with high-risk and advanced hematological malignancies and high- risk of life-threatening RRT can be transplanted effectively and safely using TREO-based regimens, and Particularly favorable results were achieved in myeloid malignancy and in children undergoing second HSCT.
Higher CD34(+) and CD3(+) cell doses in the graft promote long-term survival, and have no impact on the incidence of severe acute or chronic graft-versus-host disease after in vivo T cell-depleted
TLDR
It is demonstrated for the first time in a pediatric cohort, that higher doses of transplanted CD34(+) and CD3(+) cells lead to an improved survival without an increased risk of severe GVHD.
[Evaluation of systolic and diastolic function of the left ventricle in children with acute lymphoblastic leukaemia before treatment].
TLDR
Evaluation of cardiac function before anthracycline chemotherapy will allow to select patients with pre-existing cardiac impairment for whom cardioprotective treatment is absolutely necessary.
Steroid-sparing effect of extracorporeal photopheresis in the therapy of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
TLDR
The ECP therapy significantly reduced the rates of remissions with steroid discontinuation among cGVHD but not aGVHD patients, and Photopheresis was a safe, effective method to treat steroid-resistant cGV HD.
Increased risk of infections and infection-related mortality in children undergoing haematopoietic stem cell transplantation compared to conventional anticancer therapy: a multicentre nationwide
TLDR
The risk of any infections and the occurrence of resistant bacterial strains in allo- HSCT patients were higher than in auto-HSCT and PHO patients, while the outcome of infections was better in the PHO setting.
A prospective analysis of immune recovery in children following allogeneic transplantation of t-cell-depleted or non-T-cell-depleted hematopoietic cells from HLA-disparate family donors.
TLDR
Due to improved immune reconstitution, in spite of an increased risk of GvHD, non-TCD transplants from single HLA-mismatched family donors remain a valuable option for children without matched donors.
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