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Membrane Estrogen Receptor-α Interactions with Metabotropic Glutamate Receptor 1a Modulate Female Sexual Receptivity in Rats
TLDR
Data is presented that shows that ERα and mGluR1a directly interact to mediate a rapid estradiol-induced activation of MOR in the medial preoptic nucleus, leading to female sexual receptivity, demonstrating the physiological importance of ERα-to-mGlu R1a signaling. Expand
Membrane-Initiated Estradiol Signaling Induces Spinogenesis Required for Female Sexual Receptivity
TLDR
It is demonstrated that estradiol-induced spinogenesis in the ARH is an important cellular mechanism for the regulation of female sexual behavior. Expand
Hormonal regulation of female reproduction.
TLDR
This review focuses on several critical questions about how the HPG axis is regulated in species with different reproductive strategies, what internal and external conditions modulate the synthesis and release of GnRH, and how GnRH modulate reproductive behavior within the hypothalamus. Expand
Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats.
TLDR
Findings indicate that rapid membrane ERalpha-mGluR1a interactions activate PKCtheta cell signaling, which regulates female sexual receptivity. Expand
Menopause, obesity and inflammation: interactive risk factors for Alzheimer’s disease
TLDR
The current literature is reviewed to explore the interactions between obesity, inflammation, menopause and AD. Expand
The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice
TLDR
In humans, the opposite sex bias of APOE4 allele for microbleeds versus the plaques and tangles is the first example of organ-specific, sex-linked APOE allele effects, and further shows AD as a uniquely human condition. Expand
Modulation of the arcuate nucleus–medial preoptic nucleus lordosis regulating circuit: A role for GABAB receptors
TLDR
Results indicated that GABAB receptors were located within the lordosis-regulating ARH microcircuit and are necessary for activation and maintenance of the estradiol inhibition of lordosis behavior. Expand
Physiology of Membrane Oestrogen Receptor Signalling in Reproduction
TLDR
The interaction of membrane ERα with metabotropic glutamate receptor 1a (mGluR1a) to initiate rapid oestradiol cell signalling and its critical roles in female reproduction: sexual behaviour and oestrogen positive feedback of the luteinising hormone (LH) surge are discussed. Expand
Membrane-initiated estradiol actions mediate structural plasticity and reproduction
TLDR
This review will examine estradiol membrane signaling (EMS) activating a limbic-hypothalamic lordosis regulating circuit, which involves ERα trafficking, internalization, and modifications of neuronal morphology in a circuit that underlies female sexual receptivity. Expand
CAV1 siRNA reduces membrane estrogen receptor-α levels and attenuates sexual receptivity.
TLDR
CAV1-mediated ERα trafficking to the cell membrane is required for estradiol activation of circuits underlying female sexual receptivity. Expand
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