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Limbic activation during cue-induced cocaine craving.
OBJECTIVE Since signals for cocaine induce limbic brain activation in animals and cocaine craving in humans, the objective of this study was to test whether limbic activation occurs duringExpand
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Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
BACKGROUND Structural deficiencies within limbic and prefrontal regions may contribute to the characteristic drug-seeking and drug-taking behaviors that prevail in persons dependent on cocaine. ToExpand
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Brain metabolic changes during cigarette craving.
BACKGROUND In functional brain imaging studies, exposure to cues related to cocaine, opiates, and alcohol in dependent individuals is associated with activation of the anterior cingulate gyrus,Expand
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Conditioning factors in drug abuse: can they explain compulsion?
There is a good deal of clinical evidence suggesting that compulsion to resume drug taking is an important part of the addiction syndrome. The symptoms comprising motivation to resume drug use,Expand
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Brain Activity during Simulated Deception: An Event-Related Functional Magnetic Resonance Study
TheGuilty Knowledge Test (GKT) has been used extensively to model deception. An association between the brain evoked response potentials and lying on the GKT suggests that deception may be associatedExpand
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Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx.
Arterial spin labeling (ASL) perfusion fMRI data differ in important respects from the more familiar blood oxygen level-dependent (BOLD) fMRI data and require specific processing strategies. In thisExpand
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Telling truth from lie in individual subjects with fast event‐related fMRI
Deception is a clinically important behavior with poorly understood neurobiological correlates. Published functional MRI (fMRI) data on the brain activity during deception indicates that, on aExpand
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Classical Conditioning in Drug‐Dependent Humans a
Repetitive use of psychoactive drugs produces a variety of learned behaviors. These can be classified in the laboratory according to an operant/classical paradigm, but in vivo the two types ofExpand
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Comparing levels of cocaine cue reactivity in male and female outpatients.
Thirty-eight female and 26 male cocaine-dependent outpatients were exposed to cocaine cues in a laboratory setting. Stimuli consisted of an audiotape of patients discussing cocaine use, a videotapeExpand
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Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study
Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it hasExpand
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