A. Chiba

Publications77
h-index18
Citations1,863
Highly Influential Citations73
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Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.
  • H. Manya, A. Chiba, +5 authors T. Endo
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 13 January 2004
Defects in O-mannosylation of alpha-dystroglycan are thought to cause certain types of congenital muscular dystrophies with neuronal migration disorders. Among these muscular dystrophies,… Expand
  • 311
  • 16
Ganglioside composition of the human cranial nerves, with special reference to pathophysiology of Miller Fisher syndrome
Total ganglioside fractions from the human cranial nerves purified on a Phenyl Sepharose column, were given mild alkaline treatment, after which their composition and amounts of lipid-bound sialic… Expand
  • 247
  • 9
GM1b is a new member of antigen for serum antibody in Guillain-Barre syndrome
Serum antibody from some patients with Guillain-Barre syndrome recognized an antigen of a minor component in human brain monosialoganglioside fraction. We purified that antigen, which migrated at a… Expand
  • 93
  • 6
Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-Barré syndrome: Clinical and immunohistochemical studies
  • 66
  • 6
Experimental sensory neuropathy induced by sensitization with ganglioside GD1b
Three of six rabbits immunized with purified GD1b developed ataxic sensory neuropathy. They laid on the floor with their limbs splayed out, and their movements were awkward; but muscle power, tonus,… Expand
  • 181
  • 5
Anti-GQ1b IgG antibody is associated with ataxia as well as ophthalmoplegia.
Close association between the increase in anti-GQ1b immunoglobulin G (IgG) antibody and ophthalmoplegia in Miller Fisher syndrome (MFS) and Guillain-Barré syndrome (GBS) has been reported. We… Expand
  • 141
  • 4
Localization of GM1 and GD1b antigens in the human peripheral nervous system.
Serum antibodies against ganglioside GM1 and/or GD1b are frequently detected in autoimmune neuropathies such as multifocal motor neuropathy, IgM paraproteinemic neuropathy and Guillain-Barré… Expand
  • 82
  • 4
Targeted gene expression without a tissue-specific promoter: creating mosaic embryos using laser-induced single-cell heat shock.
We have developed a method to target gene expression in the Drosophila embryo to a specific cell without having a promoter that directs expression in that particular cell. Using a digitally enhanced… Expand
  • 59
  • 3
Upper cervical myelopathy associated with low CSF pressure
A patient who had undergone ventriculoperitoneal shunting developed upper cervical myelopathy. His CSF pressure was markedly low, and deformation of the spinal cord and shrinkage of the subarachnoid… Expand
  • 24
  • 3
N‐acetylgalactosaminyl GD1a is a target molecule for serum antibody in Guillain‐Barré syndrome
Serum antibodies against such major glycolipids as GM1, GD1b, and LM1 have been reported in patients in the acute phase of Guillain‐Barré syndrome (GBS). Because minor unidentified glycolipids also… Expand
  • 147
  • 2