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Human neutrophil alloantigens systems.
Molecular and biochemical characterization of neutrophil antigens have expanded the diagnostic tools by the introduction of genotyping techniques and immunoassays for antibody identification and further studies in the field of neutrophic immunology will facilitate the prevention and management of transfusion reactions and immune diseases caused by neutrophIL antibodies. Expand
Gene frequencies of the HPA‐15 (Gov) platelet alloantigen system in Brazilians
Summary.  The HPA‐15 (Gov) alloantigen is a biallelic co‐dominant system on human platelets, and its allele HPA‐15a and HPA‐15b differ by an A→C single nucleotide polymorphism at nucleotide 2108 ofExpand
Transfusions of CPDA‐1 red blood cells stored for up to 28 days decrease donor exposures in very low‐birth‐weight premature infants
RBC stored for up to 28 days safely reduce donor exposures in premature infants and did not cause clinical or biochemical changes and reduced donor exposures by 70·2%, according to a prospective randomized two‐group study. Expand
Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen‐2
This study investigated the presence of polymorphisms in the gene encoding HNA‐2 (CD177) in individuals presenting different patterns of antigen expression and determined the association of single nucleotide polymorphisms (SNPs) with the heterogeneous H NA‐2 expression. Expand
RHD alleles in Brazilian blood donors with weak D or D‐negative phenotypes
The RHD genotyping proved to be a necessary tool to characterise RHD alleles in donors phenotyped as D− or weak D to increase the transfusion safety in highly racial mixed population. Expand
RBC‐associated IgG in patients with visceral leishmaniasis (kala‐azar): a prospective analysis
The anemia seen in patients with visceral leishmaniasis is often multifactorial, and sequestration and destruction of the RBCs in the enlarged spleen, immune mechanisms, and alterations in RBC membrane permeability have been implicated. Expand
Allelic polymorphisms of human Fcγ receptor IIa and Fcγ receptor IIIb among distinct groups in Brazil
This work has shown that the FcγRIIA gene is expressed in two polymorphic forms, R131 and H131, which differ by the replacement of histidine by arginine at position 131. Expand
Human neutrophil alloantigen-1a, -1b, -2, -3a and -4a frequencies in Brazilians.
The determination of HNAs frequencies among populations with distinct racial backgrounds is important not only for anthropological reasons, but also for neonatal typing in suspected cases of alloimmune neutropenia or when patients are severely neutropenic. Expand
HNA‐3 gene frequencies in Brazilians and a new polymerase chain reaction–restriction fragment length polymorphism method for HNA‐3a/3b genotyping
This study determined the frequency of the HNA‐3 alleles in Brazilians and found that anti‐HNA‐ 3 are involved in severe transfusion‐related acute lung injury reactions and in neonatal alloimmune neutropenia. Expand
HPA‐9 and HPA‐3 allelic frequencies in Brazilian blood donors and Amazon Indians
This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength. Expand