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Comparative Genomics of Listeria Species
Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L.Expand
Glutathione Provides a Source of Cysteine Essential for Intracellular Multiplication of Francisella tularensis
Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularemia. Its ability to multiply and survive in macrophages is critical for its virulence. By screening a bankExpand
Role of the wbt Locus of Francisella tularensis in Lipopolysaccharide O-Antigen Biogenesis and Pathogenicity
ABSTRACT Francisella tularensis is a highly infectious bacterial pathogen, responsible for the zoonotic disease tularemia. We screened a bank of transposon insertion mutants of F. tularensis subsp.Expand
Sortase independent and dependent systems for acquisition of haem and haemoglobin in Listeria monocytogenes
We studied three Fur‐regulated systems of Listeria monocytogenes: the srtB region, that encodes sortase‐anchored proteins and a putative ABC transporter, and the fhu and hup operons, that produceExpand
Identification of the agr Locus of Listeria monocytogenes: Role in Bacterial Virulence
ABSTRACT Listeria monocytogenes is a gram-positive facultative intracellular food-borne pathogen that can cause severe infections in humans and animals. We have recently adapted signature-taggedExpand
Identification of New Genes Involved in the Virulence of Listeria monocytogenes by Signature-Tagged Transposon Mutagenesis
ABSTRACT Listeria monocytogenes is a gram-positive, facultative intracellular pathogen that can cause severe food-born infections in humans and animals. We have adapted signature-tagged transposonExpand
Adsorption of bacteriophage lambda on the LamB protein of Escherichia coli K-12: point mutations in gene J of lambda responsible for extended host range.
LamB is the cell surface receptor for bacteriophage lambda. LamB missense mutations yielding resistance to lambda group in two classes. Class I mutants block the growth of lambda with the wild-typeExpand
Francisella Tularensis Metabolism and its Relation to Virulence
Francisella tularensis is a Gram-negative bacterium capable of causing the zoonotic disease tularaemia in a large number of mammalian species and in arthropods. F. tularensis is a facultativeExpand
The heat‐shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice
Intracellular bacterial pathogens generally express chaperones such as Hsp100s during multiplication in host cells, allowing them to survive potentially hostile conditions. Francisella tularensis isExpand
Hfq, a Novel Pleiotropic Regulator of Virulence-Associated Genes in Francisella tularensis
ABSTRACT Francisella tularensis is a highly infectious pathogen that infects animals and humans, causing tularemia. The ability to replicate within macrophages is central for virulence and relies onExpand