• Publications
  • Influence
Neurobiology of migraine
Migraine is a complex disorder of the brain whose mechanisms are only now being unraveled. It is common, disabling and economically costly. The pain suggests an important role of the nociceptiveExpand
  • 184
  • 11
Neurons of the Dopaminergic/Calcitonin Gene-Related Peptide A11 Cell Group Modulate Neuronal Firing in the Trigeminocervical Complex: An Electrophysiological and Immunohistochemical Study
Activation of spinal trigeminal afferents innervating the cranial vasculature is likely to play a role in migraine, although some parts of the clinical presentation may have a dopaminergic basis. TheExpand
  • 88
  • 10
  • PDF
Animal models of headache: from bedside to bench and back to bedside
In recent years bench-based studies have greatly enhanced our understanding of headache pathophysiology, while facilitating the development of new headache medicines. At present, established animalExpand
  • 62
  • 4
Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus.
Calcitonin gene-related peptide receptor antagonists are effective acute migraine treatments without the vascular contraindications associated with triptans. While it has been demonstrated thatExpand
  • 77
  • 3
  • PDF
Dopamine: what's new in migraine?
Purpose of reviewDopamine has been implicated in the pathophysiology of migraine, although its exact role remains unclear. Recent data offer some new perspective on a possible role for dopaminergicExpand
  • 76
  • 3
Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in the rat
The ventral tegmental area (VTA) is a heterogeneous midbrain structure that contains dopamine (DA), GABA, and glutamate neurons that project to many different brain regions. Here, we combinedExpand
  • 33
  • 1
Periaqueductal gray calcitonin gene-related peptide modulates trigeminovascular neurons
Background Calcitonin gene-related peptide (CGRP) receptor antagonism is an approach to migraine therapy. The locus of action of antimigraine treatment is not resolved. The objective was toExpand
  • 26
  • 1
Trigeminocervical complex responses after lesioning dopaminergic A11 nucleus are modified by dopamine and serotonin mechanisms
Summary Lesioning the hypothalamic dopaminergic A11 nucleus facilitates trigeminal nociceptive transmission. Serotoninergic and dopaminergic inputs to the trigeminocervical complex are required forExpand
  • 28
  • 1
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma
Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL‐1&bgr; secretion fromExpand
  • 35
ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2
Background Fibrillins 1 (FBN1) and 2 (FBN2) are components of microfibrils, microfilaments that are present in many connective tissues, either alone or in association with elastin. Marfan's syndromeExpand
  • 20
  • PDF