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Characterization of Mce4A protein of Mycobacterium tuberculosis: role in invasion and survival
- N. Saini, M. Sharma, A. Chandolia, Rashmi Pasricha, V. Brahmachari, M. Bose
- Biology, Medicine
- BMC Microbiology
- 19 November 2008
BackgroundThe mce4 operon is one of the four homologues of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. The mce4A (Rv3499c) gene within this operon is homologous to mce1A… Expand
Pathogenesis of Mycoplasma pneumoniae: An update
- R. Chaudhry, A. Ghosh, A. Chandolia
- Medicine
- Indian journal of medical microbiology
- 1 January 2016
Genus Mycoplasma, belonging to the class Mollicutes, encompasses unique lifeforms comprising of a small genome of 8,00,000 base pairs and the inability to produce a cell wall under any circumstances.… Expand
An insight into the regulation of mce4 operon of Mycobacterium tuberculosis.
- Nisha Rathor, A. Chandolia, +6 authors M. Bose
- Biology, Medicine
- Tuberculosis
- 1 July 2013
The mce4 operon is reported to be involved in cholesterol utilization and intracellular survival of Mycobacterium tuberculosis (M. tuberculosis). The regulatory mechanism of this important operon was… Expand
Comparison of mammalian cell entry operons of mycobacteria: in silico analysis and expression profiling.
- Ashwani Kumar, A. Chandolia, U. Chaudhry, V. Brahmachari, M. Bose
- Biology, Medicine
- FEMS immunology and medical microbiology
- 1 February 2005
Mammalian cell entry (mce) operons, implicated in the entry of mycobacteria into host cells, are present in pathogenic and saprophytic species. It is likely that the genes in these operons have… Expand
Functional analysis of mce4A gene of Mycobacterium tuberculosis H37Rv using antisense approach.
- A. Chandolia, Nisha Rathor, +5 authors M. Bose
- Biology, Medicine
- Microbiological research
- 1 September 2014
Antisense strategy is an attractive substitute for knockout mutations created for gene silencing. mce genes have been shown to be involved in mycobacterial uptake and intracellular survival. Here we… Expand
Single nucleotide polymorphism in the genes of mce1 and mce4 operons of Mycobacterium tuberculosis: analysis of clinical isolates and standard reference strains
- Rashmi Pasricha, A. Chandolia, +6 authors M. Bose
- Biology, Medicine
- BMC Microbiology
- 23 February 2011
BackgroundThe presence of four mammalian cell entry (mce) operons in Mycobacterium tuberculosis suggests the essentiality of the functions of the genes in these operons. The differential expression… Expand
PDIM and SL1 accumulation in Mycobacterium tuberculosis is associated with mce4A expression.
Lipid metabolism forms the heart and soul of Mycobacterium tuberculosis life cycle. Starting from macrophage invasion at cholesterol rich micro-domains to a sustainable survival for infection by… Expand
Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival.
Cholesterol, an essential cellular component in macrophages, is exploited for entry and long-term survival of Mycobacterium inside the host. Cholesterol-deficient macrophages can restrict the… Expand