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Clinical staging of chronic lymphocytic leukemia.
The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients and sex and age were shown to be poor predictors of survival after adjustment for stage. Expand
Biodistribution of boronophenylalanine in patients with glioblastoma multiforme: boron concentration correlates with tumor cellularity.
The tumor:blood 10B concentration ratio derived from this analysis provides a rationale for estimating the fraction of the radiation dose to viable tumor cells resulting from the boron neutron capture reaction based on measuredboron concentrations in the blood at the time of BNCT without the need for analysis of tumor samples from individual patients. Expand
Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory.
It is feasible to safely deliver a single fraction of BPA-based BNCT in patients with GBM and, at the dose prescribed, the patients did not experience any morbidity, according to a Phase I/II trial. Expand
Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early clinical results
A Phase I/II clinical trial of boron neutroncapture therapy (BNCT) for glioblastoma multiforme is underwayusing the amino acid analog p-boronophenylalanine (BPA) andthe epithermal neutron beam at the… Expand
Biodistribution of p-boronophenylalanine in patients with glioblastoma multiforme for use in boron neutron capture therapy.
Intravenous BPA administration up to a dose of 250 mg/kg is safe and well tolerated and BPA uptake in surgical samples of glioblastoma tissue is variable and may depend on the fraction of viable tumor cells in the individual sample. Expand
Boron neutron capture therapy for malignant gliomas
The key to effective BNCT of tumours, such as glioblastoma multiforme (GBM), is the preferential accumulation of boron-10 in the tumour, including the infiltrating GBM cells, as compared with that in the vital structures of the normal brain. Expand
EXTRACORPOREAL IRRADIATION OF THE BLOOD IN HUMANS: EFFECTS UPON ERYTHROCYTE SURVIVAL
ECIB-produced red cell hemolysis of a mild degree is to be expected during courses of therapy, as demonstrated by clinical findings, but there is no doubt that acute, severe, Hemolysis could be produced by administering large doses to patients over a short period of time. Expand
The influence of extracorporeal irradiation of the blood and lymph on skin homograft rejection.
- A. Chanana, G. Brecher, E. Cronkite, D. Joel, H. Schnappauf
- Biology, Medicine
- Radiation research
- 1 March 1966
Extracorporeal irradiation of the blood has been used alone or in combination with thoracic duct drainage to produce a lymphocytopenia and to study the production and migration of lymphocytes and the depletion of lymphoreticular organs of lymphocyte by ECI has been described. Expand
Postnatal Maturation of Pulmonary Antimicrobial Defense Mechanisms in Conventional and Germ- Free Lambs
Pulmonary antimicrobial defenses in neonatal sheep were found to be deficient to some degree throughout the first 3 months of life and approximated those of adult sheep. Expand
FATE OF THYMOCYTES: STUDIES WITH 125I‐IODODEOXYURIDINE AND 3H‐THYMIDINE IN MICE
- D. Joel, A. Chanana, H. Cottier, E. Cronkite, J. Laissue
- Biology, Medicine
- Cell and tissue kinetics
- 1 January 1977
The results indicate that cortical thymocytes migrate to the spleen, mesenteric lymph node, femurs and intestine; nevertheless, only a small fraction of the activity originally present in the thymus was recovered in these organs; the vast majority of newly formed corticalThymocytes apparently die after a relatively short life span. Expand