De novo Ixodes ricinus salivary gland transcriptome analysis using two next‐generation sequencing methodologies
- A. Schwarz, B. M. Reumont, J. Erhart, A. Chagas, J. Ribeiro, M. Kotsyfakis
- BiologyThe FASEB Journal
- 1 November 2013
Detailed phylogenetic reconstructions of two relatively abundant SG‐secreted protein families demonstrated how this study improves the understanding of the molecular evolution of hematophagy in arthropods.
Lundep, a Sand Fly Salivary Endonuclease Increases Leishmania Parasite Survival in Neutrophils and Inhibits XIIa Contact Activation in Human Plasma
- A. Chagas, Fabiano Oliveira, A. Debrabant, J. Valenzuela, J. Ribeiro, E. Calvo
- Biology, MedicinePLoS Pathogens
- 1 February 2014
It is hypothesized that Lundep helps the parasite to establish an infection by allowing it to escape from the leishmanicidal activity of NETs early after inoculation and may also assist blood meal intake by lowering the local viscosity caused by the release of host DNA and as an anticoagulant by inhibiting the intrinsic pathway of coagulation.
Comparative biology of two populations of Lutzomyia umbratilis (Diptera: Psychodidae) of Central Amazonia, Brazil, under laboratory conditions.
- S. C. B. Justiniano, A. Chagas, F. A. Pessoa, R. G. Queiroz
- BiologyBrazilian journal of biology = Revista brasleira…
- 1 May 2004
Results show that the L. umbratilis population of Manaus is more productive, and thus a better candidate for future mass-rearing attempts, than the Manaus and Manacapuru populations, which differ in their life cycle, fecundity, fertility, adult longevity, and emergence.
A deep insight into the sialotranscriptome of the mosquito, Psorophora albipes
- A. Chagas, E. Calvo, C. Ríos-Velásquez, F. A. Pessoa, J. Medeiros, J. Ribeiro
- Biology, MedicineBMC Genomics
- 13 December 2013
This is the first sialome (from the Greek sialo = saliva) catalog of salivary proteins from a Psorophora mosquito, which may be useful for better understanding the lifecycle of this mosquito and the role of its Salivary secretion in arboviral transmission.
An insight into the sialome of Simulium guianense (DIPTERA:SIMulIIDAE), the main vector of River Blindness Disease in Brazil
The results contribute to understanding the role of Simulium saliva in transmission of Onchocerca volvulus and evolution of salivary proteins in black flies and to mining novel anti-hemostatic compounds, vaccine candidates against filariasis, and immuno-epidemiologic markers of vector exposure.
Aedes albopictus D7 Salivary Protein Prevents Host Hemostasis and Inflammation
The biological function of AlboD7L1 is demonstrated as an inhibitor of both platelet aggregation and cell recruitment of neutrophils and eosinophils and reinforces the physiological relevance of the D7 salivary proteins as anti-hemostatic and anti-inflammatory molecules that help blood feeding in mosquitoes.
Immunity to LuloHya and Lundep, the salivary spreading factors from Lutzomyia longipalpis, protects against Leishmania major infection
It is shown that two salivary enzymes from Lutzomyia longipalpis have a synergist effect that facilitates a more efficient blood meal intake and diffusion of other sialome components and suggests the inclusion of thesesalivary proteins as components for an anti-Leishmania vaccine.
Novel Family of Insect Salivary Inhibitors Blocks Contact Pathway Activation by Binding to Polyphosphate, Heparin, and Dextran Sulfate
- P. Alvarenga, Xueqing Xu, J. Andersen
- BiologyArteriosclerosis, Thrombosis and Vascular Biology
- 1 December 2013
The results of these studies indicate that the binding of anionic polymers by salivary proteins is used by blood feeders as an antihemostatic/anti-inflammatory mechanism.
Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes
This study shows that DC responses to Borrelia spirochetes are affected by tick cystatins, and Sialo L influences the maturation of DC thus having impact on adaptive immune response.
Collagen-binding protein, Aegyptin, regulates probing time and blood feeding success in the dengue vector mosquito, Aedes aegypti
- A. Chagas, J. Ramirez, E. Calvo
- Medicine, BiologyProceedings of the National Academy of Sciences
- 28 April 2014
The relevance of Aegyptin for A. aegypti blood feeding is demonstrated, providing further support for the hypothesis that platelet aggregation inhibition is a vital salivary function in blood feeding arthropods and indicating that multiple Salivary components work synergistically and are necessary to achieve maximum blood feeding efficiency.