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The role of Drosophila Piezo in mechanical nociception
Transduction of mechanical stimuli by receptor cells is essential for senses such as hearing, touch and pain. Ion channels have a role in neuronal mechanotransduction in invertebrates; however,Expand
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A Migrating Ciliary Gate Compartmentalizes the Site of Axoneme Assembly in Drosophila Spermatids
BACKGROUND In most cells, the cilium is formed within a compartment separated from the cytoplasm. Entry into the ciliary compartment is regulated by a specialized gate located at the base of theExpand
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The stum Gene Is Essential for Mechanical Sensing in Proprioceptive Neurons
Touchy-Feely Genes All animals need accurate proprioceptive sensation to control motor function. Desai et al. (p. 1256) identified a Drosophila mutant with impaired walking coordination. The affectedExpand
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Dissection of Gain Control Mechanisms in Drosophila Mechanotransduction
Mechanoreceptor cells respond to a vast span of stimulus intensities, which they transduce into a limited response-range using a dynamic regulation of transduction gain. Weak stimuli are detected byExpand
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NOMPC-dependent mechanotransduction shapes the dendrite of proprioceptive neurons
Animal locomotion depends on proprioceptive feedback which is generated by mechanosensory neurons. We recently demonstrated that the evolutionarily conserved stumble (stum) gene is essential forExpand
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Routing of opsin to the cilium
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The route of the visual receptor rhodopsin along the cilium
ABSTRACT The photoreceptor outer segment is the most elaborate primary cilium, containing large amounts of rhodopsin (RHO) in disk membranes that grow from a connecting cilium. The movement of RHOExpand
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The Effect of Stress on Motor Function in Drosophila
Exposure to unpredictable and uncontrollable conditions causes animals to perceive stress and change their behavior. It is unclear how the perception of stress modifies the motor components ofExpand
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Physical Medicine & Rehabilitation
First person – Abhishek Chadha
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongsideExpand